Dynarrestin - ≥98%(HPLC) , CAS No.2222768-84-3

CAS: 2222768-84-3 Cat. No.: D286946 Molecular Weight: 431.5

GRADE & PURITY ≥98%(HPLC)

Synonyms

Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate | 4-(4-Diethylaminophenyl)-2-(2,4-difluoro-phenylamino)-thiazole-5-carboxylic acid ethyl ester

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

Ethyl 4-(4-(diethylamino)phenyl)-2-((2, 4-difluorophenyl)amino)thiazole-5-carboxylate | 4-(4-Diethylaminophenyl)-2-(2, 4-difluoro-phenylamino)-thiazole-5-carboxylic acid ethyl ester

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Dynein inhibitor. Inhibits hedgehog signalingin vitro(IC50= 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 504773517
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773517
• Canonical Smiles: CCN(CC)C1=CC=C(C=C1)C2=C(SC(=N2)NC3=C(C=C(C=C3)F)F)C(=O)OCC
• IUPAC Name: ethyl 4-[4-(diethylamino)phenyl]-2-(2,4-difluoroanilino)-1,3-thiazole-5-carboxylate
• InChIKey: UZNNDDDSGCMQOQ-UHFFFAOYSA-N
• INCHI: 1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)
• Molecular Weight: 431.5
• Reaxy-Rn: 32644520
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32644520&ln=

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 43.15, Max Conc. mM: 100
• Sensitivity: Light sensitive
• Molecular Weight: 431.500 g/mol
• XLogP3: 6.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 431.148 Da
• Monoisotopic Mass: 431.148 Da
• Topological Polar Surface Area: 82.700 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 546.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1