Enfumafungin - 10mM in DMSO , CAS No.260979-95-1

CAS: 260979-95-1 Cat. No.: E655840 Formula: C₃₈H₆₀O₁₂ Peso molecolare: 708.88

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus ) and does not inhibit the growth of Bacillus subtilis

In Vitro

Enfumafungin (24-48 h) has MICs of less than 0.5 μg/mL against the Candida and Aspergillus species tested and it is inactive against Cryptococcus , including the decapsulated form (MY2062). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Enfumafungin (50-200 mg/kg; i.p. twice daily for 2 days) produces a significant decrease in the number of c.f.u. in kidneys of mice challenged with C. albicans , with an ED 90 of 90 mg/kg . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:(1,3)-beta-D-glucan synthase

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specifi

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Tipo di azione

INHIBITOR

Nomi e identificatori

• Peso molecolare: 708.88