Enoxolone - Moligand™, 10mM in DMSO , Inhibitor of hydroxysteroid 11-beta dehydrogenase 1;Inhibitor of hydroxysteroid 11-beta dehydrogenase 2, CAS No.471-53-4, Inhibitor of hydroxysteroid 11-beta dehydrogenase 1;Inhibitor of hydroxysteroid 11-beta dehydrogenase 2

CAS: 471-53-4 Cat. No.: E407903 Molecular Weight: 470.68 Beilstein Registry Number: 2229654 EC Number: 207-444-6
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
Glycyrrhetin | Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Status
Price
Qty
1ml
E407903-1ml
2

$98.90

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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 29 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Enoxolone Enoxolone (Glycyrrhetin) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.
In vitro


In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥95%

Specifications

Synonyms
Glycyrrhetin | Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β, 20β)-
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
Enoxolone (Glycyrrhetin) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of hydroxysteroid 11-beta dehydrogenase 1;Inhibitor of hydroxysteroid 11-beta dehydrogenase 2
Names and Identifiers
Isomeric SMILES C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O
WGK Germany 3
RTECS RK0180000
Molecular Weight 470.68
Beilstein 2229654
Reaxy-Rn 3041142
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3041142&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
HSD11B2 Tchem Corticosteroid 11-beta-dehydrogenase isozyme 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HSD11B1 Tclin Corticosteroid 11-beta-dehydrogenase isozyme 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
Specific Rotation[α]162 ° (C=1, MeOH)
Melt Point(°C)292-295°C
Documents & Articles
Citations of This Product
References
1. Seongsu Kang, Jiwon Park, Zhihong Cheng, Sanghyun Ye, Seung-Hyun Jun, Nae-Gyu Kang.  (2024)  Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+) by Synergistic Inhibition of CD38 Expression.  Cells,  13  (21): (1799).  [PMID:39513906] [10.3390/cells13211799]
2. Baoyuan Zhang, Yixin Sun, Shengbo Yuan, Shufang Zheng, Yongke Zhang, Zuo Zhang, Dongyu Zhang, Jiayu Guo, Xianbao Shi, Jin Sun, Zhonggui He, Bingjun Sun.  (2025)  Glycyrrhetinic acid-albumin nanoparticles with bimodal pharmacological activities for time-dependent restoration of acute liver injury.  Nano Today,      [PMID:] [10.1016/j.nantod.2025.102849]
3. Xuewa Jiang, Shaoyan Yi, Pingping Shen, Richa Raj, Jian Zhang, Haixia Ge.  (2025)  Insights on the synergistic effects of glycyrrhetinic acid and isoliquiritigenin on HMGB1-induced inflammation by multi-spectroscopic and molecular docking studies.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:40714661] [10.1016/j.saa.2025.126726]
4. Zhenhua Li, Junjie Zhang, Chuanyong Fan, Kaifang Wu, Jiaping Liu, Yaru Zhang, Zehao Dong, Fang Dong, Lu Xu.  (2025)  Degradable glycyrrhetinic acid functionalized mesoporous silica nanoparticles enhanced liver cancer therapy.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,      [PMID:41038589] [10.1016/j.ejpb.2025.114880]
5. Linjun Zou, Yong Hou, Jiawen Zhang, Meiying Chen, Peiying Wu, Changcun Feng, Qinglong Li, Xudong Xu, Zhaocui Sun, Guoxu Ma.  (2023)  Degradable carrier-free spray hydrogel based on self-assembly of natural small molecule for prevention of postoperative adhesion.  Materials Today Bio,      [PMID:37593217] [10.1016/j.mtbio.2023.100755]
6. Qing Yao, Yingying Tang, Sheng Dai, Lihui Huang, Zewei Jiang, Shiming Zheng, Meng Sun, Yitianhe Xu, Ruijie Lu, Tuyue Sun, Huirong Huang, Xinyu Jiang, Xiaomin Yao, Guangyong Lin, Longfa Kou, Ruijie Chen.  (2023)  A Biomimetic Nanoparticle Exerting Protection against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS.  Advanced Healthcare Materials,      [PMID:37236618] [10.1002/adhm.202300571]
7. Liu Cui, Xi Wang, Zhaoyun Liu, Ziqi Li, Ziwei Bai, Kui Lin, Jian Yang, Yuanlu Cui, Fei Tian.  (2023)  Metal-organic framework decorated with glycyrrhetinic acid conjugated chitosan as a pH-responsive nanocarrier for targeted drug delivery.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:37044320] [10.1016/j.ijbiomac.2023.124370]
8. Wen Zhijie, Fu Hudie, Ye Xuexin, Yang Xuedan, Zhu Shengpeng, Hu Jie, Kang Li, Li Xiaojun, Yang Xinzhou, Hu Yan.  (2023)  Antitumor activities of novel glycyrrhetinic acid-modified lipogel hybrid system in vitro.  JOURNAL OF MATERIALS SCIENCE,  58  (13): (5788-5807).  [PMID:] [10.1007/s10853-023-08394-7]
9. Jie Hu, Yongsheng Zheng, Zhijie Wen, Hudie Fu, Xuedan Yang, Xuexin Ye, Shengpeng Zhu, Li Kang, Xiaojun Li, Xinzhou Yang, Yan Hu.  (2023)  Construction of redox-sensitive liposomes modified by glycyrrhetinic acid and evaluation of anti-hepatocellular carcinoma activity.  CHEMISTRY AND PHYSICS OF LIPIDS,      [PMID:36931583] [10.1016/j.chemphyslip.2023.105292]
10. Fanli Shi, Ruilong Li, Wenjing Wang, Xiangyu Yu, Fenxia Zhu, Yiping Huang, Jing Wang, Zhenhai Zhang.  (2023)  Carboxymethyl starch as a solid dispersion carrier to enhance the dissolution and bioavailability of piperine and 18β-glycyrrhetinic acid.  DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,      [PMID:36803327] [10.1080/03639045.2023.2182120]
11. Yanmin Shen, Ruoyu Li, Peixia Zhao, Wenju Liu, Xiaolong Yang, Zheng Zhang.  (2022)  Equilibrium Solubility of 18β-Glycyrrhetinic Acid in 12 Pure Solvents: Determination, Correlation, and Hansen Solubility Parameter.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.2c00399]
12. Li Li, Anqi Chen, Bingmi Liu, Hao Pan, Yanjie Yu, Yu Liu.  (2022)  Preparation and pharmacokinetics of glycyrrhetinic acid and cell transmembrane peptides modified with liposomes for liver targeted-delivery.  Biomedical Materials,  17  (4): (045006).  [PMID:35483344] [10.1088/1748-605X/ac6b73]
13. Lulu Jin, Zhixin Zhu, Liangjie Hong, Zhefeng Qian, Fang Wang, Zhengwei Mao.  (2022)  ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation.  Bioactive Materials,      [PMID:35415314] [10.1016/j.bioactmat.2022.03.040]
14. Di Zhang, Jianxin Sun, Shiquan Chang, Xing Li, Huimei Shi, Bei Jing, Yachun Zheng, Yi Lin, Guoqiang Qian, Yuwei Pan, Guoping Zhao.  (2021)  Protective effect of 18β‑glycyrrhetinic acid against H2O2‑induced injury in Schwann cells based on network pharmacology and experimental validation.  Experimental and Therapeutic Medicine,  22  (5): (1-9).  [PMID:34539837] [10.3892/etm.2021.10676]
15. Feng Yunhui, Mei Liyan, Wang Maojie, Huang Qingchun, Huang Runyue.  (2021)  Anti-inflammatory and Pro-apoptotic Effects of 18beta-Glycyrrhetinic Acid In Vitro and In Vivo Models of Rheumatoid Arthritis.  Frontiers in Pharmacology,      [PMID:34381358] [10.3389/fphar.2021.681525]
16. Hao Liu, Sijiao Wang, Houyin Shi, Ruirui Zhang, Kunyan Qu, Yue Hu, Xingyu Qu, Chenyun Gan, Jingjing Chen, Xinyu Shi, Mengwu Zhang, Weiling Zeng.  (2021)  Gastric floating tablet improves the bioavailability and reduces the hypokalemia effect of gossypol in vivo.  SAUDI PHARMACEUTICAL JOURNAL,      [PMID:33994825] [10.1016/j.jsps.2021.03.001]
17. Ruoning Wang, Xin Wang, Xiaoshun Jia, Honglan Wang, Wen Li, Junsong Li.  (2020)  Impacts of particle size on the cytotoxicity, cellular internalization, pharmacokinetics and biodistribution of betulinic acid nanosuspensions in combined chemotherapy.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:32828973] [10.1016/j.ijpharm.2020.119799]
18. Li Li, Shasha Han, Chun Yang, Lin Liu, Sengqun Zhao, Xiaofang Wang, Bingmi Liu, Hao Pan, Yu Liu.  (2020)  Glycyrrhetinic acid modified MOFs for the treatment of liver cancer.  NANOTECHNOLOGY,  31  (32): (325602).  [PMID:32320964] [10.1088/1361-6528/ab8c03]
19. Kaili Wang, Chunjing Guo, Shaohua Zou, Yueming Yu, Xinxin Fan, Bingjie Wang, Mengna Liu, Lei Fang, Daquan Chen.  (2018)  Synthesis, characterization and in vitro/in vivo evaluation of novel reduction-sensitive hybrid nano-echinus-like nanomedicine.  Artificial Cells Nanomedicine and Biotechnology,      [PMID:29703084] [10.1080/21691401.2018.1466147]
20. Saisai Wang, Yong Shen, Runfeng Qiu, Zhiliang Chen, Zhehang Chen, Wenbin Chen.  (2017)  18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration.  INTERNATIONAL JOURNAL OF ONCOLOGY,  51  (2): (615-624).  [PMID:28656212] [10.3892/ijo.2017.4059]
21. Ping Zhang, Yang Cao, Huali Chen, Bo Zhou, Wenjing Hu, Liangke Zhang.  (2017)  Preparation and evaluation of glycyrrhetinic acid-modified and honokiol-loaded acoustic nanodroplets for targeted tumor imaging and therapy with low-boiling-point phase-change perfluorocarbon.  Journal of Materials Chemistry B,  (29): (5845-5853).  [PMID:32264217] [10.1039/C7TB01215B]
22. Dagen Zhong, Zonghua Liu, Shasha Xie, Wei Zhang, Yuanming Zhang, Wei Xue.  (2012)  Study on poly(D,L-lactic) microspheres embedded in calcium alginate hydrogel beads as dual drug delivery systems.  JOURNAL OF APPLIED POLYMER SCIENCE,  129  (2): (767-772).  [PMID:] [10.1002/app.38797]
23. Ma Xuan, Sun Zhenou, Chen Hui, Cao Lixing, Zhao Shuang, Fan Lihong, Zhao Chong, Yin Shutao, Hu Hongbo.  (2024)  18β-glycyrrhetinic acid suppresses Lewis lung cancer growth through protecting immune cells from ferroptosis.  CANCER CHEMOTHERAPY AND PHARMACOLOGY,      [PMID:38383823] [10.1007/s00280-024-04639-7]
24. Qianhui Zhao, Xinhang Li, Jun Wen, Yinhui He, Nenggan Zheng, Wenchang Li, Albert Cardona, Zhefeng Gong.  (2024)  A two-layer neural circuit controls fast forward locomotion in Drosophila.  CURRENT BIOLOGY,      [PMID:39053465] [10.1016/j.cub.2024.06.060]
25. Haining Hou, Zehao Zhang, Haibo Li.  (2025)  Developing spherical Cu@C electrode with three-dimensional multi-channels for high-capacity and high-rate capacitive desalination.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.131715]
26. Yanru Liu, Ya Hu, Xiaoxia Xie, Gongjun Yang, Fang Feng.  (2025)  The bioactive ingredients and mechanisms of Wen-Pi-Tang in treating chronic renal failure, based on UHPLC-Q-Exactive Orbitrap MS, network pharmacology, and in silico validation.  NEW JOURNAL OF CHEMISTRY,      [PMID:] [10.1039/D5NJ01333J]
27. Bai Ge, Liu Hongwen, Li Wei, Chen Sijia, Wang Lishan, Wang Zhangding, Zhou Yue, Pan Yani, Liu Yu, Chen Qi, Zhang Nannan, Wei Jingjing, Fu Xueni, Zhou Yaru, Zhu Yun, Xu Lei, Wang Lei.  (2025)  Mitochondria-targeting polymer cLipG/CuET activates the cGAS/STING pathway to enhance cholangiocarcinoma immunotherapy.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-17).  [PMID:41068916] [10.1186/s12951-025-03689-0]
28. Xuanzhi Luo, Yuan Zeng, Xue Wang, Mujin Li, Ya-Lei Wang, Tiantian Peng, Cuiyan Ma, Qian Hua.  (2026)  18ï ¢-Glycyrrhetinic acid suppresses glioblastoma by regulating p38 signaling pathway: an integrative approach combining network analysis, transcriptomics, and experimental assessment.  Frontiers in Pharmacology,      [PMID:41782932] [10.3389/fphar.2026.1727072]
29. Zijin Sun, Jingxian Niu, Baicun Chen, Hangyan Ji, Chao Qiu, Qianzhu Lin, Zhengyu Jin.  (2026)  Electrostatic bridging of glycyrrhizic acid to enhance the properties of Pickering emulsion gel stabilized by cinnamaldehyde-tannic acid-chitosan particles.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2026.108669]
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