≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with K i s of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs , respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418.
In Vitro
Epiboxidine hydrochloride has affinity and functional at central neuronal α4β2 receptors, with K i s of 0.46 and 1.2 in rat and humen. Epiboxidine hydrochloride has activity at ganglionic-type α3β4*-nicotinic receptors of PC12 cells, with a K i of 19. Epiboxidine hydrochloride is much less toxic than Epibatidine. Epiboxidine hydrochloride stimulates sodium-22 influx in PC12 and TE671 cells, with EC 50 s of 0.18 and 2.6 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Epiboxidine hydrochloride (20 μg/kg; ip; once) treatment shows marked analgetic activity in mice . Epiboxidine hydrochloride (50 and 100 mg/kg; intraperitoneal injected; once) causes marked antinociception as measured in the hot-plate assay. Epiboxidine hydrochloride inhibits [ 3 H]nicotine binding in rat cerebral cortical membranes, with a K i of 0.6 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
Specifications
Specifiche e purezza
≥99%
Meccanismi biochimici e fisiologici
Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with K i s of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs , respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analo
Condizioni di conservazione di stoccaggio
Store at -20°C,Desiccated
Spedito in
Ice chest + Ice pads
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Tipo di azione
AGONIST
Purezza
≥99%
Nomi e identificatori
Peso molecolare
214.69
Documentazione
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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