Epothilone A - 10mM in DMSO , CAS No.152044-53-6

CAS: 152044-53-6 Cat. No.: E409291 Formula: C₂₆H₃₉NO₆S Peso molecolare: 493.66

QUALITÀ & PUREZZA 10mM in DMSO

Synonyms

(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Epothilone A Epothilone A is a paclitaxel-like microtubule -stabilizing agent with EC 0.01 of 2 μM.
In vitro

Epothilone A, discovered from the myxobacterium Sorangium cellulosum, is a Taxol-like microtubule-stabilizing agent that induces tubulin polymerization, leading to cell cycle arrest at the G2-M transition, cytotoxicity, and apoptosis.Epothilone A potently inhibits cell proliferation in HCT116 cells, with IC50 of 4.4 nM. Epothilone A also displays cytotoxicity in KB3-1, KBV-1, Hela, and Hs578T cells, with IC50 values ranging from 13 nM to 160 nM. Epothilone A is more water soluble than Taxol and competes with Taxol in binding with microtubules, with IC50 of 2.3 μM. However, both Epothilone A and Taxol don\'t share a common pharmacophore and exploits the tubulin-binding pocket uniquely and independently. Recently, it is found that microbiological transformation of Epothilone A by Aspergillus niger AS 3.739 yields several metabolites that is also toxic to MCF-7 cells, but with much higher IC50 values.

In vivo

Cell Data

cell lines：A431, MO7e, HUVEC and NHDF cells

Concentrations：0–2 μM

Incubation Time：24 hours for mitotic arrest or 72 hours for cytotoxicity

Powder Purity:≥98%

Specifiche

Sinonimi

(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC_0.01 of 2 μM.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Nomi e identificatori

Isomeri SMILES

C[C@H]1CCC[C@@H]2[C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C

WGK Germania

3

Peso molecolare

493.66

Reaxy-Rn

26220988

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26220988&ln=