Etrinabdione - 10mM in DMSO , CAS No.1818428-24-8

CAS: 1818428-24-8 Cat. No.: E656473 Formula: C₂₈H₃₅NO₃ Peso molecolare: 433.58 PubChem CID: 118465221

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Etrinabdione (EHP-101; VCE-004.8) is an orally active, specific PPARγ and CB 2 receptor dual agonist. Etrinabdione inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway. Etrinabdione, a semi-synthetic multitarget cannabinoquinoid, has potent anti-inflammatory activity. Etrinabdione attenuates adipogenesis and prevents diet-induced obesity

In Vivo

Etrinabdione (i.p.; 20?mg/kg/day; for 3 weeks) induces a significant reduction in body weight gain, total fat mass, adipocyte volume and plasma triglycerides levels in HFD mice. Etrinabdione can also significantly ameliorate glucose tolerance, reduce leptin levels (a marker of adiposity) and increase adiponectin and incretins (GLP-1 and GIP) levels . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:PPARγ CB2

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Etrinabdione (EHP-101; VCE-004.8) is an orally active, specific PPARγ and CB 2 receptor dual agonist. Etrinabdione inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway. Etrinabdione, a semi-synthetic multitarget cannabinoquinoid, has potent a

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Isomeri SMILES: CCCCCC1=C(C(=C(C(=O)C1=O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O)NCC3=CC=CC=C3
• CAS alternativo: 1818428-24-8
• PubChem CID: 118465221
• Peso molecolare: 433.58