10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker ( K i =0.4 µM) for the research of schizophrenia. Evenamide shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness
In Vitro
Evenamide selectively blocks voltage-gated sodium channels (VGSCs) in a voltage-and use-dependent manner (K i =0.4 µM) and modulates sustained repetitive firing without inducing impairment of the normal neuronal excitability. Evenamide does not bind, inhibit or interact with over 130 receptors, enzymes, or transporters. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Evenamide is active in a wide range of psychiatric animal models in monotherapy and addon to antipsychotics. Evenamide is effective in attenuating the social interaction deficit in Cl 395 (PCP)-impaired rats (MED=1 mg/kg po). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:Sodium channel
Specifications
Specifiche e purezza
10mM in DMSO
Meccanismi biochimici e fisiologici
Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker ( K i =0.4 µM) for the research of schizophrenia. Evenamide shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness
Condizioni di conservazione di stoccaggio
Store at -80°C
Spedito in
Dry ice packs + Cold packs
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Tipo di azione
BLOCKER
Meccanismo d'azione
Sodium channel alpha subunit blocker
Proprietà del prodotto
ALogP
2.5
Nomi e identificatori
Isomeri SMILES
CCCCOC1=CC=CC(=C1)CCNCC(=O)N(C)C
CAS alternativo
1092977-61-1
PubChem CID
25105689
Peso molecolare
278.39
Documentazione
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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Recensioni
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Domande frequenti
How should this product be stored?
Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1092977-61-1, the molecular formula is C16H26N2O2, and the molecular weight is 278.39 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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