1-(2-Furfuryl)-2-Thiourea: Handling & Lab Use Guidelines

1-(2-Furfuryl)-2-thiourea is a heterocyclic thiourea derivative featuring a furan ring linked via a methylene bridge to the thiourea nitrogen, making it a versatile building block and reagent in synthetic organic chemistry research.

Product Name

1-(2-Furfuryl)-2-thiourea

SKU / Catalog Number

T698800

Chemical Class

Heterocyclic thiourea derivative

Core Structural Features

Furan ring, methylene linker, thiourea functional group

Typical Application

Synthetic intermediate and ligand precursor in organic and medicinal chemistry research

Supplier

Aladdin Scientific

Chemical Identity and Structure

1-(2-Furfuryl)-2-thiourea (Aladdin SKU: T698800) is an organosulfur compound belonging to the thiourea family. Its structure consists of a thiourea core [SC(NH₂)NH–] in which one nitrogen atom is substituted with a 2-furfurylmethyl group derived from furfurylamine. The furan ring contributes aromatic character and potential for hydrogen-bond interactions, while the thiourea moiety provides both hydrogen-bond donor and acceptor sites along with a soft sulfur donor atom. This combination of functional groups makes the compound relevant as a chelating ligand precursor, a nucleophilic sulfur source, and a scaffold for further derivatization in heterocyclic synthesis.

Key structural features:

• Molecular formula: C₆H₈N₂OS (verify against certificate of analysis)
• Functional groups: furan ring, secondary amine (NH), primary amine (NH₂), thione (C=S)
• Potential tautomerism between thione and thiol forms

Safe Handling and Storage

As with all thiourea-containing compounds, 1-(2-Furfuryl)-2-thiourea should be handled with appropriate laboratory precautions. Thioureas in general are classified as potential irritants, and some members of this class have been associated with thyroid-disrupting activity in high-dose animal studies; researchers should consult the current Safety Data Sheet (SDS) for T698800 before use.

Recommended precautions:

• Personal Protective Equipment (PPE): Wear nitrile gloves, safety goggles, and a laboratory coat. If handling as dust or powder, use a half-face respirator with appropriate cartridge.
• Ventilation: Work in a well-ventilated fume hood, especially when weighing or dissolving the compound.
• Storage: Store in a tightly sealed container in a cool, dry place away from strong oxidizers and direct sunlight. Confirm specific temperature requirements from the product label or SDS.
• Waste Disposal: Dispose of residues and contaminated materials according to local institutional and regulatory guidelines for organosulfur compounds.

Note: Specific GHS hazard classifications and first-aid measures must be confirmed from the official SDS provided by Aladdin Scientific at the time of purchase.

Applications in Research

1-(2-Furfuryl)-2-thiourea serves several roles in synthetic and medicinal chemistry research laboratories:

• Heterocyclic synthesis: The thiourea group can participate in condensation reactions with carbonyl compounds (aldehydes, ketones, and active-methylene species) to construct thiazolidine, dihydropyrimidinthione, and related ring systems. The furfuryl moiety adds additional reactivity and can itself undergo ring-opening or cross-coupling reactions under appropriate conditions.
• Metal coordination chemistry: The sulfur and nitrogen donor atoms of the thiourea unit make this compound a candidate ligand precursor for transition-metal complexes. Such complexes may be evaluated for catalytic or biological activity.
• Biological screening: Thiourea derivatives bearing furan substituents have been investigated in the literature as potential antimicrobial and antifungal scaffolds. T698800 may therefore serve as a starting material or reference compound in medicinal chemistry programs.
• Analytical chemistry: Thioureas are known to form stable complexes with certain heavy metals and may find use in chelation-based detection or extraction methodologies.

Researchers should validate suitability for each specific application through appropriate experimental controls.

Preparation of Stock Solutions

The following guidance provides a general framework for preparing solutions of 1-(2-Furfuryl)-2-thiourea. Exact solubility data should be confirmed experimentally or from the product SDS/technical datasheet.

1. Solvent selection: Thiourea derivatives with mixed polar/aromatic character are commonly soluble in polar aprotic solvents such as DMSO and DMF, and may show moderate solubility in lower alcohols (methanol, ethanol). Aqueous solubility may be limited and should be tested empirically.
2. Concentration: Prepare an initial stock at a concentration appropriate for downstream dilution (e.g., 10–100 mM in DMSO). Filter through a 0.2 µm PTFE syringe filter if particulates are observed.
3. Stability: Aliquot stock solutions to avoid repeated freeze-thaw cycles. Store aliquots at –20 °C under inert atmosphere (argon or nitrogen) if long-term storage is required. Monitor for color change or precipitation as indicators of degradation.
4. Compatibility: Avoid strongly alkaline or acidic conditions unless these are required by the specific protocol, as extreme pH may hydrolyze the thiourea group.

All solubility and stability data cited above are general estimates for thiourea-class compounds; confirm experimentally for T698800.

Quality and Regulatory Considerations

When procuring and using 1-(2-Furfuryl)-2-thiourea (T698800) from Aladdin Scientific, researchers and procurement personnel should consider the following:

• Purity verification: Request the Certificate of Analysis (CoA) for the specific lot number received. Key analytical parameters typically include purity by HPLC or GC, melting point, and spectroscopic confirmation (NMR, MS). Confirm these are appropriate for your experimental requirements.
• Regulatory status: This compound is supplied for research use only (RUO) and is not intended for diagnostic, therapeutic, or food-contact applications without appropriate regulatory authorization.
• Lot-to-lot consistency: For long-term studies, note the lot number and contact Aladdin Scientific procurement to request matched lots where consistency is critical.
• Export control: Organosulfur compounds may be subject to national export control regulations in certain jurisdictions. Procurement teams should verify compliance before international shipping.

Frequently asked questions

What solvents are recommended for dissolving 1-(2-Furfuryl)-2-thiourea?

Polar aprotic solvents such as DMSO or DMF are generally suitable starting points for thiourea derivatives. Moderate solubility may be observed in alcohols such as methanol or ethanol. Aqueous solubility should be tested empirically, as it may be limited. Always confirm solubility experimentally for your specific application and concentration requirements.

How should 1-(2-Furfuryl)-2-thiourea (T698800) be stored to maintain stability?

Store the compound in a tightly sealed container in a cool, dry place away from light and strong oxidizers. For dissolved stocks intended for long-term use, aliquot and store at –20 °C under an inert atmosphere to minimise degradation and avoid repeated freeze-thaw cycles. Confirm precise storage conditions from the Aladdin Scientific product label and SDS.

Is 1-(2-Furfuryl)-2-thiourea suitable for biological or in vivo studies?

T698800 is supplied as a research-use-only (RUO) reagent and has not been validated for diagnostic or therapeutic use. Thiourea compounds as a class may exhibit biological activity including potential endocrine effects at high doses based on general literature for the thiourea class; researchers must conduct appropriate cytotoxicity and safety assessments before any biological application. Consult your institutional biosafety and ethics guidelines.

Where can I obtain the Certificate of Analysis and Safety Data Sheet for T698800?

The Certificate of Analysis (CoA) and Safety Data Sheet (SDS) for T698800 are available through the Aladdin Scientific website product page or by contacting Aladdin Scientific customer service directly. Always request the CoA for your specific received lot number to confirm purity and analytical data.

References

1. General reference: March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley-Interscience. (For thiourea chemistry background.)
2. Aladdin Scientific product page for T698800: 1-(2-Furfuryl)-2-thiourea. Aladdin Scientific (accessed via www.aladdin-e.com).
3. General reference: Houben-Weyl Methods of Organic Chemistry: Organosulfur compounds including thioureas. Georg Thieme Verlag. (For thiourea synthesis and reactivity.)

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.