Diallyl Trisulfide
Diallyl Trisulfide
Diallyl trisulfide (DATS, Aladdin D302734 ≥65%) and diallyl tetrasulfide (DTS) are organosulfur compounds naturally derived from garlic and other Allium species. These molecules are formed as decomposition products of Allicin (Aladdin A303933≥80% mixture, A424615 10mM in DMSO ), which is released when garlic is crushed.
Organosulfur compounds display a wide range of biological effects. DATS and DTS contribute significantly to garlic’s antibacterial activity, inhibiting the growth of pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli.
In animal models of diabetes, DATS improves cardiac performance by enhancing PI3K–Akt signaling, thereby protecting against both death receptor–mediated and mitochondria-dependent apoptosis, ultimately alleviating diabetic cardiomyopathy.
Both compounds also show anticancer potential. Their antioxidative properties are thought to contribute to their chemotherapeutic activity. In leukemia cells, DATS elevates ROS production and activates caspases, leading to apoptosis and inhibition of proliferation. In parallel studies, DTS treatment was associated with microtubule depolymerization and G2/M phase cell cycle arrest.
DTS has additional effects on signaling pathways. It activates JNK signaling, resulting in phosphorylation of Bcl-2 and induction of apoptosis. DTS also irreversibly inhibits Cdc25, which promotes cell cycle arrest and suppresses proliferation in breast cancer cells.
Beyond direct anticancer activity, DATS and DTS may act as chemopreventive agents. In animal models of skin carcinogenesis, DATS reduced the number and multiplicity of papillomas induced by TPA.
In addition to DATS and DTS, Aladdin provides a variety of related garlic-derived compounds, including Diallyl Sulfide (D101110 ≥98%), Allyl Disulfide (D432326 ≥96%, D109400 ≥85%), L-Deoxyalliin (I137523 ≥98%, S422599 10mM in Water), L-Alliin (L276129 ≥98% ), and L-(+)-Alliin (A424735 10mM in DMSO, A110693 ≥90%, A110692 analytical standard ≥98%).
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