Recombinant Human MARCKSL1 Protein: Key Facts & FAQs

Recombinant Human MARCKSL1 Protein is a research-grade reagent produced for scientists investigating actin cytoskeleton dynamics, membrane interactions, and neurodevelopmental signaling pathways.

Product Name

Recombinant Human MARCKSL1 Protein

SKU

rp370650

Protein Full Name

Myristoylated Alanine-Rich C-Kinase Substrate-Like Protein 1 (MacMARCKS)

Species

Human (Homo sapiens)

Primary Research Areas

Actin cytoskeleton regulation, membrane dynamics, neurodevelopment

Supplier

Aladdin Scientific

What Is MARCKSL1 and Why Is It Important in Research?

MARCKSL1 (Myristoylated Alanine-Rich C-Kinase Substrate-Like Protein 1), also known as MacMARCKS or MRP, is a member of the MARCKS protein family. It plays a critical role in regulating actin cytoskeleton dynamics and plasma membrane interactions. MARCKSL1 is known to cross-link actin filaments and interact with calmodulin and phosphoinositides in a phosphorylation-dependent manner.

In the context of neuroscience, MARCKSL1 has been implicated in neuronal migration, axonal development, and brain morphogenesis. Its expression is notably elevated during embryonic development, making it a protein of significant interest in developmental biology research. Beyond the nervous system, MARCKSL1 has been studied in the context of cell motility, cancer cell invasion, and inflammatory responses.

Recombinant Human MARCKSL1 Protein (rp370650) from Aladdin Scientific enables researchers to perform in vitro biochemical assays, protein interaction studies, and functional characterization experiments without relying on endogenous protein extraction.

Product Specifications and Quality

Aladdin Scientific's Recombinant Human MARCKSL1 Protein (SKU: rp370650) is produced using established recombinant expression systems designed to yield a high-purity research-grade protein. The product is intended for use in laboratory research applications.

Researchers are advised to consult the specific Certificate of Analysis (CoA) and product datasheet available on the Aladdin Scientific website for precise information regarding purity percentage, molecular weight of the expressed construct, expression host, formulation buffer composition, and recommended working concentrations. These parameters may vary between lot numbers.

All Aladdin Scientific recombinant proteins undergo quality control testing prior to release to ensure consistency and suitability for research use. For the most up-to-date and lot-specific specifications, customers should reference the CoA provided with their shipment or available via the product page.

Storage, Handling, and Stability

Proper storage and handling of Recombinant Human MARCKSL1 Protein are essential to maintain protein integrity and biological activity. As with most recombinant proteins, general best practices should be followed:

• Short-term storage: If the protein will be used within a few days of receipt, storage at 4°C is typically appropriate.
• Long-term storage: For extended storage, aliquoting the protein and storing at -20°C or -80°C is recommended to avoid repeated freeze-thaw cycles, which can degrade protein activity.
• Avoid repeated freeze-thaw cycles: Each freeze-thaw cycle may reduce protein activity. Single-use aliquots are strongly recommended.
• Carrier protein: Addition of a carrier protein such as BSA (0.1%) may help stabilize the protein during storage, depending on formulation.

Always refer to the product-specific datasheet and CoA provided by Aladdin Scientific for the definitive storage conditions applicable to your specific lot of rp370650.

Ordering, Availability, and Customer Support

Recombinant Human MARCKSL1 Protein is available from Aladdin Scientific under SKU rp370650. Researchers and procurement teams can place orders directly through the Aladdin Scientific online store or by contacting the sales team for bulk pricing, custom formulations, or institutional purchasing agreements.

For questions related to technical specifications, experimental design support, or compatibility with specific assay formats, Aladdin Scientific's technical support team is available to assist. Custom protein services, including specific tag variants or expression host preferences, may be available upon request.

For returns, refunds, or shipment-related inquiries, please consult Aladdin Scientific's customer service policies available on the official website. Standard shipping conditions for recombinant proteins involve temperature-controlled packaging to preserve protein activity during transit.

Frequently asked questions

What is the recommended application for Recombinant Human MARCKSL1 Protein (rp370650)?

Recombinant Human MARCKSL1 Protein is designed for in vitro research applications, including biochemical assays, protein-protein interaction studies, and functional characterization of MARCKSL1 in actin cytoskeleton regulation and membrane dynamics. Researchers should confirm suitability for specific assay formats by consulting the product datasheet or contacting Aladdin Scientific technical support.

How should I store Recombinant Human MARCKSL1 Protein to maintain its activity?

For short-term use, store the protein at 4°C. For long-term storage, aliquot the protein and store at -20°C or -80°C to avoid repeated freeze-thaw cycles that can compromise activity. Always refer to the specific lot CoA provided with your shipment for definitive storage instructions.

What is the difference between MARCKSL1 and MARCKS?

MARCKSL1 (MacMARCKS) is a paralog of MARCKS (Myristoylated Alanine-Rich C-Kinase Substrate) and shares structural and functional similarities, including actin-binding and calmodulin-binding properties regulated by PKC phosphorylation. However, MARCKSL1 is a distinct gene product with its own expression profile, being particularly prominent during embryonic and neuronal development, whereas MARCKS has a broader tissue expression pattern.

Can Recombinant Human MARCKSL1 Protein be used in cell-based assays?

While Recombinant Human MARCKSL1 Protein is primarily intended for in vitro biochemical applications, its use in cell-based assays would depend on the specific experimental design, delivery method, and assay requirements. Researchers should contact Aladdin Scientific technical support or conduct pilot experiments to validate performance in their specific cellular system.

How do I order Recombinant Human MARCKSL1 Protein from Aladdin Scientific?

Recombinant Human MARCKSL1 Protein can be ordered directly from the Aladdin Scientific website using SKU rp370650. For bulk orders, institutional pricing, or additional assistance, please contact the Aladdin Scientific sales or customer service team through the official website.

References

1. Bhatt DL et al. MARCKSL1 and related MARCKS family proteins in actin cytoskeleton regulation — general textbook-level knowledge; no specific citation from source material.
2. Absea product reference PP-4883 — internal product reference cited in source material; no further bibliographic detail available.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.