Ribonucleases cleave RNA by recognizing specific bases, nucleic acid hybrid structures, or double-stranded RNA conformations, and have distinct application positions in nucleic acid purification, structural analysis, gene regulation, and disease mechanism research.
RNA structure analysis often requires distinguishing single-stranded regions, double-stranded regions, stacked regions, and differences in structural accessibility. RNase T1, RNase A, RNase V1, and S1 nuclease can be used as structural probes. By selectively cleaving different conformational or ...
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