Flurbiprofen - Moligand™, 10mM in DMSO , Channel blocker of ASIC1;Inhibitor of COX-1;Inhibitor of COX-2, CAS No.5104-49-4, Channel blocker of ASIC1;Inhibitor of COX-1;Inhibitor of COX-2

CAS: 5104-49-4 Cat. No.: F408049 Molecular Weight: 244.27 EC Number: 225-827-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2-Fluoro-α-methyl-[1,1'-biphenyl]-4-acetic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).
In vitro

Flurbiprofen effectively inhibits the growth of various tumor cells in a dose-dependent manner and causes a noticeable change in the progression of cells through cell cycle stages in tumor cell lines derived from medulloblastoma and glioblastoma multiforme. Flurbiprofen reduces the number of cells in G1 and G2, and significantly increases their numbers in S phase, suggesting that, Flurbiprofen accelerates G1/S entry, and/or delays cell exit from S to G2/M stages. Flurbiprofen causes a minor change in the RNA level of different cyclins, there is a significant decrease in the level of cyclin B protein upon flurbiprofen treatment.

In vivo

Flurbiprofen affords significant neuroprotection from ischemic injury as evidenced by reduction in cerebral infarct volume and neurobehavioral deficit. Flurbiprofen significantly reduces an early calcium dependent rise in levels of nitrite and MDA in ischemic brain regions of rats. Flurbiprofen also reduces the proteolytic products (SBDPs) caused by ischemic activation of calcium dependent protease calpain. Flurbiprofen (5 mg/kg and 10mg/kg) significantly attenuates brain ischemia/reperfusion injury in rats, as shown by a reduction in the infarct volume, neurological deficit scores and cell apoptosis. Flurbiprofen not only inhibits the expression of Bax protein and p-GSK-3β, but also increases the expression of Bcl-2 protein, the ratio of Bcl-2/Bax as well as the P-Akt level in rats.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

2-Fluoro-α-methyl-[1, 1'-biphenyl]-4-acetic acid

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

CHANNEL BLOCKER, INHIBITOR

Mechanism of action

Channel blocker of ASIC1;Inhibitor of COX-1;Inhibitor of COX-2

Product Properties

• ALogP: 4.2

Names and Identifiers

• Isomeric SMILES: CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
• RTECS: DU8341000
• Molecular Weight: 244.27
• Reaxy-Rn: 2054451
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2054451&ln=

Associated Targets(Human)

PTGS1 Tclin Prostaglandin G/H synthase 1 (3 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (4 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ASIC1 Tchem Acid-sensing ion channel 1 (1 Activities)

Discover Target: ASIC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 113 °C

References

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2. Zhipeng Huang, Yang Yang, Junju Mu, Genheng Li, Jianyu Han, Puning Ren, Jian Zhang, Nengchao Luo, Ke-Li Han, Feng Wang.  (2023)  Controlling the reactions of free radicals with metal-radical interaction.  CHINESE JOURNAL OF CATALYSIS,      [PMID:] [10.1016/S1872-2067(22)64181-0]

3. Qianqian Shang, Huajing Liu, Hang Mei, Chuixiu Huang, Xiantao Shen.  (2022)  Multi-extraction system with identical supported semi-liquid membrane: Enhanced stability for coextraction of acidic and basic drugs.  TALANTA,      [PMID:35462249] [10.1016/j.talanta.2022.123485]

4. Yuemei Cen, Haihang Wang, Ping Wen, Genying Xu, Feng Tian, Fenggang Bian, Xiangqiong Zeng.  (2022)  The development of an artificial skin membrane mimicking the lipid bilayer structure for in vitro permeation study.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2022.128609]

5. Ruiqin Zhu, Hang Mei, Huajing Liu, Changbao Hong, Xiantao Shen, Chuixiu Huang.  (2021)  Successive liquid-phase microextraction of acidic and basic analytes.  ANALYTICA CHIMICA ACTA,      [PMID:35057942] [10.1016/j.aca.2021.339335]

6. Shan Chen, Shu Zhou, Jinli Fu, Sisi Tang, Xiaodan Wu, Pengfei Zhao, Zhaohui Zhang.  (2021)  A near infrared fluorescence imprinted sensor based on zinc oxide nanorods for rapid determination of ketoprofen.  Analytical Methods,  13  (25): (2836-2846).  [PMID:34080589] [10.1039/D1AY00555C]

7. Xu Xu, Feng Xue, Liu Zhen, Xue Shan, Zhang Lei.  (2021)  3D flower-liked Fe3O4/C for highly sensitive magnetic dispersive solid-phase extraction of four trace non-steroidal anti-inflammatory drugs.  MICROCHIMICA ACTA,  188  (2): (1-10).  [PMID:33496871] [10.1007/s00604-021-04708-1]

8. Wang Zhongyan, Ren Chunhua, Shang Yuna, Yang Cuihong, Guo Qingxiang, Chu Liping, Liu Jianfeng.  (2020)  Co-assembled Supramolecular Nanofibers With Tunable Surface Properties for Efficient Vaccine Delivery.  Frontiers in Chemistry,      [PMID:32850613] [10.3389/fchem.2020.00500]

9. Xuemei Wang, Wei Zhou, Chenlu Wang, Zilin Chen.  (2018)  Cotton fiber-supported layered double hydroxides for the highly efficient adsorption of anionic organic pollutants in water.  NEW JOURNAL OF CHEMISTRY,  42  (12): (9463-9471).  [PMID:] [10.1039/C8NJ00678D]

10. Nadeem Muhammad, Qamar Subhani, Fenglian Wang, Dandan Guo, Qiming Zhao, Shuchao Wu, Yan Zhu.  (2017)  Application of a simple column-switching ion chromatography technique for removal of matrix interferences and sensitive fluorescence determination of acidic compounds (pharmaceutical drugs) in complex samples.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:28807548] [10.1016/j.chroma.2017.07.007]

11. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo.  (2015)  Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs.  MICROCHIMICA ACTA,  182  (15): (2585-2591).  [PMID:] [10.1007/s00604-015-1638-x]

12. Hang Mei, Huajing Liu, Qianqian Shang, Ying Dong, Stig Pedersen-Bjergaard, Chuixiu Huang, Xiantao Shen.  (2021)  Organic-solvent-free electromembrane extraction based on semi-interpenetrating polymer networks.  GREEN CHEMISTRY,  23  (4): (1782-1793).  [PMID:] [10.1039/D1GC00148E]

13. Zheng-Kang Luo, Hui-Min Qin, Jin-Meng Han, Jin Zhu, Yu-Yu Zeng, Chang-Ping Fan, Shu-Xian Liu, Chao Hao, Jian Zhang, Tao Zhuang.  (2024)  Novel drug-drug co-amorphous systems of olaparib with nonsteroidal anti-inflammatory drugs with improved solubility, physical stability, antitumor activity and pharmacokinetics.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2024.106232]

14. Peng Pan, Sixv Ding, Wang Yang, Yibo Wang, Hua Qian, Ayang Zhao, Wengang Ding.  (2025)  Flurbiprofen@ZIF-8 nanoformulation with potential for analgesia.  BMC Anesthesiology,      [PMID:41331754] [10.1186/s12871-025-03467-3]