Foscarnet Sodium - 10mM in Water , CAS No.63585-09-1

CAS: 63585-09-1 Cat. No.: F408966 Formula: CNa₃O₅P Peso molecolare: 191.95 Numero EC: 695-653-7 PubChem CID: 44561

GRADE & PURITY 10mM in Water

Synonyms

Phosphonoformate | Phosphinecarboxylic acid, 1,1-dihydroxy-, 1-oxide, sodium salt (1:3)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Foscarnet Sodium Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.
In vitro

Foscarnet Sodium is able to penetrate into cells and inhibit viral replication by inhibiting viral DNA synthesis. Foscarnet Sodium (300 μM) displays a more than 95% inhibition on HTLV-III reverse transcriptase activity in H9 cells infected with HTLV-III. Foscarnet Sodium has a low cellular toxicity, but shows an inhibition of cell proliferation at high concentrations, which is reversed after drug removal. Incubation 0.5-1 mM Foscarnet Sodium with HeLa cells or primary human lung fibroblast for 24-48 hr inhibited 50% DNA synthesis and/or cell proliferation. Foscarnet Sodium is able to bind with the heparin-binding domain of FGF2 and inhibits FGF2 induced cell proliferation. Foscarnet Sodium (25 μM) treating HUVEC cells for 48 hr reduced FGF2-induced cellular proliferation by 20%. Foscarnet Sodium (0.5-1 mM) reduced the 24h proliferation rate of CAL-62 cell, a Human thyroid anaplastic carcinoma cell line which expresses FGF2, to nearly 80%.

In vivo

Foscarnet Sodium display an efficient therapy effect on animal with virus diseases, such as cutaneous infection, herpes keratitis, genital infection, or systemic and interacerebral infection. For example, Foscarnet Sodium (100 mM) applied at initiated 48 h post inoculation with twice daily applications of 30 μL for 4 days, displays a more than 70% reduction in cumulative score after inoculation with HSV-1 strain C42. Foscarnet Sodium (20 mg/kg) given as an aerosol to mice infected with murine CMV caused a reduction of 60% in lung titers.
Cell Data

cell lines：

Concentrations：~1.5 mM

Incubation Time：48 hours

Powder Purity:≥98%

Specifications

Sinonimi

Phosphonoformate | Phosphinecarboxylic acid, 1,1-dihydroxy-, 1-oxide, sodium salt (1:3)

Specifiche e purezza

10mM in Water

Meccanismi biochimici e fisiologici

Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

Isomeri SMILES

C(=O)([O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+]

PubChem CID

44561

Peso molecolare

191.95

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 63585-09-1, the molecular formula is CNa3O5P, and the molecular weight is 191.95 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.