G0-C14 , CAS No.1510653-27-6

CAS: 1510653-27-6 Cat. No.: G649380 Formula: C₁₀₆H₂₁₆N₁₀O₁₀ Peso molecolare: 1790.91

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

Drug Delivery, Surface Modification, PEGylation of Protein, Peptide & Oligo

Panoramica

G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery.

In Vitro

G0-C14 exhibits strong entrapment of mRNA and pDNA with an encapsulation efficiency of above 95%. Preparation of NPs:\n1.Dissolve PolyHCPT and DSPE-PEG3K in DMF to form a homogenous solution at a concentration of 5 mg/mL.\n2.Prepare a mixture of 1 nmol of siRNA (0.1 nmol/µL aqueous solution) and G0-C14 (5 mg/mL in DMF) in different N/P molar ratios. Mixed them with the polyHCPT and DSPE-PEG3K solution.\n3.Under vigorous stirring (1000 rpm), add the mixture dropwise to 5 mL of deionized water.\n4.Transferr the formed NP dispersion to an ultrafiltration device.\n5.Ccentrifug at room temperature (2800 rpm×8 min) to remove the organic solvent and free compounds. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Oil

Specifiche

Meccanismi biochimici e fisiologici

G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

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Nomi e identificatori

Peso molecolare

1790.91