GDC-0575 (ARRY-575) - 10mM in DMSO , CAS No.1196541-47-5

CAS: 1196541-47-5 Cat. No.: G408434 Formula: C₁₆H₂₀BrN₅O Peso molecolare: 378.27

GRADE & PURITY 10mM in DMSO

Synonyms

RG7741 | Cyclopropanecarboxam​ide, N-​[4-​[(3R)​-​3-​amino-​1-​piperidinyl]​-​5-​bromo-​1H-​pyrrolo[2,​3-​b]​pyridin-​3-​yl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

GDC-0575 (ARRY-575, RG7741) is a potent and selectiveCHK1inhibitor with an IC50 of 1.2 nM.
In vitro

GDC-0575 enhances the cytotoxicity of Cytarabine (AraC) in vitro.

In vivo

GDC-0575 is a highly-selective oral small-molecule Chk1 inhibitor that results in tumor shrinkage and growth delay in xenograft models.
Cell Data

cell lines：various cancer cell lines belonging to 4 types of cancer—breast, ovarian, prostate, and endometrial cancer—in which the PIK3CA mutation and PTEN deficiency are frequently found and in which RAS/RAF is rarely mutated

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinonimi

RG7741 | Cyclopropanecarboxam​ide, N-​[4-​[(3R)​-​3-​amino-​1-​piperidinyl]​-​5-​bromo-​1H-​pyrrolo[2,​3-​b]​pyridin-​3-​yl]​-

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

GDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2\u2009nM.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Proprietà del prodotto

ALogP

1.621

hba_count

2

Conteggio HBD

3

Legame rotabile

3

Nomi e identificatori

Isomeri SMILES

C1C[C@H](CN(C1)C2=C3C(=CNC3=NC=C2Br)NC(=O)C4CC4)N

Peso molecolare

378.27

Reaxy-Rn

39067843

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=39067843&ln=

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 7 mg/mL (28.84 mM); Ethanol: 5 mg/mL (20.6 mM); Water: Insoluble
• DMSO (mg/mL) Solubilità massima: 75
• DMSO (mM) Solubilità massima: 198.271076215402
• Acqua (mg/mL) Solubilità massima: ＜1

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1196541-47-5, the molecular formula is C16H20BrN5O, and the molecular weight is 378.27 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.