Gelsemine - 10mM in DMSO , CAS No.509-15-9

CAS: 509-15-9 Cat. No.: G424380 Formula: C₂₀H₂₂N₂O₂ Peso molecolare: 322.4 Numero EC: 208-095-2

QUALITÀ & PUREZZA 10mM in DMSO

Synonyms

GELSEMINE|509-15-9|Gelsemin|5Y13A78Z72|NSC-21729|UNII-5Y13A78Z72|HSDB 3488|gelsemine free base|(+)-Gelsemine|EINECS 208-095-2|NSC 21729|BRN 5406576|GELSEMIN [HSDB]|GELSEMINE [MI]|GELSEMINE [WHO-DD]|GELSEMINE, (+)-|(3R-(3alpha,4abeta,5alpha,8alpha,8abeta,9

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Gelsemine is a CNS stimulant derived from the roots and rhizome of Gelsemium sempervirens.

Specifiche

Sinonimi

GELSEMINE | 509-15-9 | Gelsemin | 5Y13A78Z72 | NSC-21729 | UNII-5Y13A78Z72 | HSDB 3488 | gelsemine free base | (+)-Gelsemine | EINECS 208-095-2 | NSC 21729 | BRN 5406576 | GELSEMIN [HSDB] | GELSEMINE [MI] | GELSEMINE [WHO-DD] | GELSEMINE, (+)- | (3R-(3alpha,4abeta,5alpha,8alpha,8abeta,9

Specifiche e purezza

10mM in DMSO

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

Pubchem Sid

528776115

Sorrisi canonici

CN1CC2(C3CC4C5(C2C1C3CO4)C6=CC=CC=C6NC5=O)C=C

IUPAC Name

(1'R,2'S,3S,5'S,6'S,8'R,11'S)-2'-ethenyl-4'-methylspiro[1H-indole-3,7'-9-oxa-4-azatetracyclo[6.3.1.02,6.05,11]dodecane]-2-one

InChIKey

NFYYATWFXNPTRM-QJICHLCESA-N

INCHI

1S/C20H22N2O2/c1-3-19-10-22(2)16-11-9-24-15(8-13(11)19)20(17(16)19)12-6-4-5-7-14(12)21-18(20)23/h3-7,11,13,15-17H,1,8-10H2,2H3,(H,21,23)/t11-,13+,15+,16+,17-,19-,20-/m0/s1

Isomeri SMILES

CN1C[C@]2([C@@H]3C[C@@H]4[C@]5([C@H]2[C@H]1[C@H]3CO4)C6=CC=CC=C6NC5=O)C=C

Peso molecolare

322.4

Reaxy-Rn

102312

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=102312&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Alkaloids and derivatives
    • Classe Gelsemium alkaloids

• Kingdom: Organic compounds
• Superclass: Alkaloids and derivatives
• Classe: Gelsemium alkaloids
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Gelsemium alkaloids
• Alternative Parents: Indolines Isoindolines Aralkylamines Oxepanes Benzenoids Piperidines Oxanes N-alkylpyrrolidines Amino acids and derivatives Trialkylamines Secondary carboxylic acid amides Lactams Dialkyl ethers Oxacyclic compounds Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Gelsemium skeleton - Indole or derivatives - Dihydroindole - Isoindoline - Isoindole or derivatives - Aralkylamine - Oxepane - Benzenoid - N-alkylpyrrolidine - Piperidine - Oxane - Pyrrolidine - Carboxamide group - Amino acid or derivatives - Lactam - Tertiary aliphatic amine - Tertiary amine - Secondary carboxylic acid amide - Oxacycle - Azacycle - Carboxylic acid derivative - Dialkyl ether - Ether - Organoheterocyclic compound - Amine - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Carbonyl group - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as gelsemium alkaloids. These are alkaloids with a structure that is based on the tetracyclic gelsemium skeleton. These alkaloids contain an oxindole function and a cage-like, hydroaromatic residue which is believed to arise from an intermediate related to anhydrovobasinediol by formation of a 6,20 bond and rearrangement to an oxindole. The major alkaloids in this group are related to Gelsemine; however, a smaller group, characterized by Gelsedine, lack the 6,20 bond, and have also lost C-21.
• External Descriptors: Indole alkaloids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

GLRA1 Tclin Glycine receptor subunit alpha-1 (1 Activities)

Discover Target: GLRA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

A-431 (6446 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KB (17409 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLRA1 Tclin Glycine receptor (alpha-1/beta) (119 Activities)

Discover Target: GLRA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLRA3 Tchem Glycine receptor alpha-3/beta (286 Activities)

Discover Target: GLRA3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLRA2 Tchem Glycine receptor subunit alpha-2/beta (1 Activities)

Discover Target: GLRA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Obiettivi associati (non umani)

Glra1 Glycine receptor subunit alpha-1 (65 Activities)

Discover Target: Glra1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P388 (20296 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Punto di fusione (°C): 180-181° C
• Peso molecolare: 322.400 g/mol
• XLogP3: 1.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 322.168 Da
• Monoisotopic Mass: 322.168 Da
• Topological Polar Surface Area: 41.600 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 635.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 7
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1