Ginkgolide A - Moligand™, 10mM in DMSO , Antagonist of PAF receptor, CAS No.15291-75-5, Antagonist of PAF receptor

CAS: 15291-75-5 Cat. No.: G407818 Formula: C₂₀H₂₄O₉ Peso molecolare: 408.4 Numero EC: 604-873-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

BN52020 | (1R,​3S,​3aS,​4R,​6aR,​7aR,​7bR,​8S,​10aS,​11aS)​-3-​(1,​1-​dimethylethyl)​hexahydro-​4,​7b-​dihydroxy-​8-​methyl-9H-​1,​7a-​(epoxymethano)​-​1H,​6aH-​cyclopenta[c]​furo[2,​3-​b]​furo[3',​2':3,​4]​cyclopenta[1,​2-​d]​furan-​5,​9,​12(4H)​-​trione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Ginkgolide A Ginkgolide A (BN52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a K i of 14.5 μM.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥95%

Specifications

Sinonimi

BN52020 | (1R,​3S,​3aS,​4R,​6aR,​7aR,​7bR,​8S,​10aS,​11aS)​-3-​(1,​1-​dimethylethyl)​hexahydro-​4,​7b-​dihydroxy-​8-​methyl-9H-​1,​7a-​(epoxymethano)​-​1H,​6aH-​cyclopenta[c]​furo[2,​3-​b]​furo[3',​2':3,​4]​cyclopenta[1,​2-​d]​furan-​5,​9,​12(4H)​-​trione

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Ginkgolide A (BN52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a K_i of 14.5 μM.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

ANTAGONIST

Meccanismo d'azione

Antagonist of PAF receptor

Nomi e identificatori

• Isomeri SMILES: CC1C(=O)OC2C1(C34C(=O)OC5C3(C2)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O
• WGK Germania: 3
• Peso molecolare: 408.4
• Reaxy-Rn: 9155792
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9155792&ln=

Obiettivi associati (umani)

PTAFR Tchem Platelet-activating factor receptor (1 Activities)

Discover Target: PTAFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Riferimenti

1. Yuan Gang Zu, Lingling Wang, Xiuhua Zhao, Yuanyuan Li, Weiwei Wu, Chang Zu, Yannian Huang, Mingfang Wu, Ziqi Feng.  (2016)  Purification of Ginkgo biloba Extract by Antisolvent Recrystallization.  CHEMICAL ENGINEERING & TECHNOLOGY,  39  (7): (1301-1308).  [PMID:] [10.1002/ceat.201500691]

2. Meng Wang, Xiangling Sun, Ying Wang, Xuan Deng, Jianing Miao, Donghe Zhao, Kunqi Sun, Minrui Li, Xiaoyi Wang, Wenlong Sun, Jie Qin.  (2022)  Construction of Selenium Nanoparticle-Loaded Mesoporous Silica Nanoparticles with Potential Antioxidant and Antitumor Activities as a Selenium Supplement.  ACS Omega,      [PMID:36530304] [10.1021/acsomega.2c04975]

3. Lingling Wang, Xiuhua Zhao, Fengjian Yang, Weiwei Wu, Yanjie Liu, Li Wang, Lu Wang, Zijian Wang.  (2019)  Enhanced bioaccessibility in vitro and bioavailability of Ginkgo biloba extract nanoparticles prepared by liquid anti-solvent precipitation.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  54  (6): (2266-2276).  [PMID:] [10.1111/ijfs.14141]

4. Lingling Wang, Xiuhua Zhao, Yuangang Zu, Weiwei Wu, Yuanyuan Li, Chang Zu, Yin Zhang.  (2016)  Enhanced dissolution rate and oral bioavailability of ginkgo biloba extract by preparing nanoparticles via emulsion solvent evaporation combined with freeze drying (ESE-FR).  RSC Advances,  6  (81): (77346-77357).  [PMID:] [10.1039/C6RA14771B]