GRADE & PURITYAnalytical standard?Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods.≥99%
Antiproliferative agent. Inhibits melanogenesis. Induces apoptosis through caspase 3, 8, and 9 activation and PARP cleavage. Activates ERK1/2, p38 MAPK and JNK1/2. Shows estrogenic, neuroprotective, depigmenting and antitumor effects in vivo.
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Analytical standard
Action Type
INHIBITOR
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as pyranoisoflavonoids. These are isoflavonoids that contain a pyran ring fused to either of the A, B, or C ring of the isoflavonoid skeleton.
External Descriptors
Isoflavans
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Chunxing Pan, Xiaoying Liu, Yating Zheng, Zejun Zhang, Yongliang Li, Biao Che, Guangrong Liu, Lanyue Zhang, Changzhi Dong, Haji Akber Aisa, Zhiyun Du, Zhengqiang Yuan. (2022) The mechanisms of melanogenesis inhibition by glabridin: molecular docking, PKA/MITF and MAPK/MITF pathways. Food Science and Human Wellness, [PMID:][10.1016/j.fshw.2022.07.011]
2.Lu Wang, Qiong Liu, Baoxian Ye. (2020) An electroanalytical method for glabridin investigation based on poly(diallyldimethylammonium chloride)-functionalized graphene-modified electrode. MICROCHEMICAL JOURNAL, [PMID:][10.1016/j.microc.2020.105279]
3.Mei-yuan Li, Zhi-peng Jia, De-min Li, Man-ping Luo, Ying-ying Meng, Kang- xu Wang, Bei Wang, Bing Liu, Xin-guo Zhang, Qin Li. (2024) Enhanced co-extraction of glycyrrhizic acid and glabridin from Glycyrrhiza glabra L. through enzyme-focused techniques. INDUSTRIAL CROPS AND PRODUCTS, [PMID:][10.1016/j.indcrop.2024.118145]
4.Weng Jiyu, Wang Ying, Tan Zekai, Yuan Yanghe, Huang Shiyuan, Li Zexi, Li Yiming, Zhang Lanyue, Du Zhiyun. (2024) Glabridin reduces neuroinflammation by modulating inflammatory signals in LPS-induced in vitro and in vivo models. INFLAMMOPHARMACOLOGY, [PMID:38372849][10.1007/s10787-023-01424-5]
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A2207560