Glaucocalyxin A - 10mM in DMSO , CAS No.79498-31-0

CAS: 79498-31-0 Cat. No.: G655210 Molecular Weight: 332.43 PubChem CID: 10471963

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect

In Vitro

Glaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:PI3K

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effec

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C[C@@]12CCC(=O)C([C@H]1C[C@H]([C@]34[C@H]2CC[C@H]([C@H]3O)C(=C)C4=O)O)(C)C
• Alternate CAS: 79498-31-0
• PubChem CID: 10471963
• MeSH Entry Terms: (7R,14R)-ent-7,14,dihydroxy-(-)-kaur-16-en-3,15-dione;glaucocalyxin A
• Molecular Weight: 332.43

Associated Targets(Human)

GP6 Tchem Platelet glycoprotein VI (2 Activities)

Discover Target: GP6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)