GLP-1-(9-36), Antagonist of GLP-1 receptor, CAS No.rp174138, Antagonist of GLP-1 receptor

CAS: rp174138 Cat. No.: rp174138
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QUALITÀ & PUREZZA Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
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Dimensione
Germania (EU)
USA*
Prezzo
Qtà
500μg
rp174138-500μg
Su ordinazione · 8–12 settimane
2.082,49€
1mg
rp174138-1mg
Su ordinazione · 8–12 settimane
3.470,87€
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Perché questa qualità

Moligand™ Moligand™ per flussi di lavoro cromatografici e analitici sensibili che richiedono un'interferenza minima della linea di base.

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Stoccaggio e spedizione

Room temperature Spedizione . Consultare il COA specifico del lotto per le specifiche esatte.

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Prova documentale

Citato in 0 pubblicazioni peer-reviewed su cromatografia, sintesi organica e reazioni di accoppiamento incrociato.

Specifiche

Product Name
GLP-1-(9-36), Antagonist of GLP-1 receptor, CAS No.rp174138
Grado
Moligand™
Specifiche e purezza
Moligand™
Tipo di azione
ANTAGONIST
Meccanismo d'azione
Antagonist of GLP-1 receptor
CAS
rp174138
Tipo di molecola
Peptidi
Product Line
Prodotti biologici
Stoccaggio e spedizione
Condizioni di conservazione di stoccaggio
Room temperature

Documentazione

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Dati avanzati

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic Polymers
ClassePolypeptides
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentPolypeptides
Alternative Parents Peptides  Tyrosine and derivatives  Phenylalanine and derivatives  Arginine and derivatives  Glutamine and derivatives  Glutamic acid and derivatives  Leucine and derivatives  Isoleucine and derivatives  Aspartic acid and derivatives  Tetracarboxylic acids and derivatives  Valine and derivatives  N-acyl-alpha amino acids and derivatives  Tryptamines and derivatives  Alpha amino acid amides  Serine and derivatives  Alanine and derivatives  3-alkylindoles  Amphetamines and derivatives  1-hydroxy-2-unsubstituted benzenoids  Amino fatty acids  Hydroxy fatty acids  Substituted pyrroles  N-acyl amines  Heteroaromatic compounds  Secondary carboxylic acid amides  Guanidines  Primary carboxylic acid amides  Secondary alcohols  Amino acids  Carboxylic acids  Carboximidamides  Azacyclic compounds  Primary alcohols  Hydrocarbon derivatives  Imines  Monoalkylamines  Organopnictogen compounds  Carbonyl compounds  Organic oxides  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Polypeptide - Alpha peptide - Tyrosine or derivatives - Arginine or derivatives - Phenylalanine or derivatives - Glutamine or derivatives - Glutamic acid or derivatives - Aspartic acid or derivatives - Leucine or derivatives - Isoleucine or derivatives - N-acyl-alpha amino acid or derivatives - Tetracarboxylic acid or derivatives - Valine or derivatives - Alpha-amino acid amide - Triptan - Serine or derivatives - Alanine or derivatives - Amphetamine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - 3-alkylindole - Indole or derivatives - Indole - 1-hydroxy-2-unsubstituted benzenoid - Amino fatty acid - Phenol - Hydroxy fatty acid - Fatty amide - Substituted pyrrole - N-acyl-amine - Monocyclic benzene moiety - Fatty acyl - Benzenoid - Heteroaromatic compound - Pyrrole - Amino acid or derivatives - Amino acid - Carboxamide group - Guanidine - Secondary carboxylic acid amide - Secondary alcohol - Primary carboxylic acid amide - Carboxylic acid derivative - Carboximidamide - Carboxylic acid - Organoheterocyclic compound - Azacycle - Primary alcohol - Organopnictogen compound - Imine - Amine - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organic nitrogen compound - Primary aliphatic amine - Alcohol - Organic oxide - Organonitrogen compound - Organooxygen compound - Primary amine - Aromatic heteropolycyclic compound
DescrizioneThis compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
External Descriptors Not available
Obiettivi associati (umani)
GLP1R Tclin Glucagon-like peptide 1 receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Informazioni genetiche
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more
Calcolatori di soluzioni
Recensioni

Recensioni dei clienti

Application Protocols

No validated, item-specific protocols are provided for this product. The following general procedures are offered as practical guidance for peptide handling (not specifications):

  • Reconstitution (general):
    1. Allow vial to reach room temperature before opening. 2) Add water or mildly acidic buffer (e.g., 10–20 mM acetate, pH 4.5–5.5) to achieve a convenient stock concentration. 3) If needed, pre-wet with a small volume of DMSO, then dilute with buffer. 4) Mix gently to avoid foaming; do not vortex excessively.
  • Working solutions: Prepare fresh daily or aliquot stocks and freeze to avoid repeated freeze–thaw. Include carrier protein or a non‑ionic surfactant for low‑ng/mL applications to reduce adsorption.
  • LC/LC‑MS standard prep: Dilute in 0.1% formic acid in water; add 2–10% acetonitrile to improve spray stability. Store chilled during sequences.
  • Bioconjugation setup: Desalt into reaction buffer (e.g., HEPES pH 8.0 for NHS esters), perform reaction at RT with gentle agitation, then quench and purify by RP‑HPLC or SEC.

Documentation:

  • Record solvent, pH, exact concentration, and lot number in notebooks/ELN. Verify identity and purity post‑prep by LC‑MS for critical experiments.

For assay‑specific parameters (concentrations, incubation times), consult your method SOPs or literature relevant to GLP‑1 fragments.

Biological Roles

Context (literature, for background only; not a product claim):

  • Origin: GLP‑1(9–36) is a circulating peptide fragment produced by dipeptidyl peptidase‑4 (DPP‑4) cleavage of GLP‑1(7–36) amide, removing the N‑terminal His‑Ala dipeptide.
  • Receptor considerations: Unlike full‑length GLP‑1(7–36), the 9–36 fragment exhibits markedly reduced activity at the canonical GLP‑1 receptor in many assay systems. It is frequently used as a negative or mechanistic control in GLP‑1 pathway studies.
  • Biochemical behavior: Retains the physicochemical hallmarks of GLP‑1 peptides (aqueous solubility, susceptibility to proteolysis, adsorption to plastics), making handling comparable to other incretin peptides.
  • Metabolic relevance: Serves as a model analyte in studies of peptide hormone degradation, DPP‑4 activity, and peptide pharmacokinetics in vitro (no clinical claims).

Use in research:

  • A tool for dissecting fragment vs full‑length peptide effects in cell‑free or biochemical assays.
  • A reference analyte for LC‑MS quantitation in biomarker method development (e.g., surrogate matrices), pending suitable internal standards.

Important: Functional outcomes can be assay‑dependent and sequence‑specific. Verify sequence, termini (amide vs acid), and any modifications on the CoA, and design controls accordingly.

Buffer Applications

This item is a peptide research reagent rather than a buffering compound. Nonetheless, appropriate buffers are central to successful handling and assays.

General buffer guidance (not item-specific):

  • Preparation of stock solutions:
    • Dissolve in water or mildly acidic buffer (e.g., 10–20 mM acetate, pH 4.5–5.5) to aid solubility; then adjust to target assay buffer.
    • For neutral pH work, PBS (pH 7.2–7.4) or HEPES (pH 7.4) are common. Keep ionic strength moderate to reduce aggregation.
  • Working concentrations: Typical assay stocks are 0.1–1 mM; dilute to final nM–µM concentrations as needed. Verify by UV or quantitative amino acid analysis as appropriate.
  • Stabilizers/additives: 0.01–0.1% carrier protein (e.g., BSA) or 0.01–0.05% non‑ionic surfactant can mitigate adsorption to plastics; confirm compatibility with your assay.
  • Filtration: If sterile solutions are required, filter through 0.22 µm low‑binding membranes.

Not a classical buffering agent: There is no defined pKa set or buffering range for this peptide suitable for use as a buffer. Select buffer systems based on the downstream biological or analytical protocol.

Green Alternatives

For peptide handling, the greenest choice is typically to maximize aqueous media and minimize hazardous organics.

Greener selections (general guidance):

  • Prefer water and mild aqueous buffers (acetate, phosphate, HEPES) over organic solvents for dissolution, purification, and analysis when feasible.
  • Reduce DMSO usage by dissolving first in a small volume of acidic water, then adjusting pH; reserve DMSO as a co‑solvent only if necessary.
  • Use ethanol or isopropanol (if compatible) for equipment rinse instead of chlorinated solvents.

Comparison (typical pros/cons):

| Option | Pros | Cons | |---|---|---| | Water/buffer | Non-toxic, biodegradable, assay-compatible | Limited for highly hydrophobic sequences | | DMSO | Strong solubilizer; miscible with water | High EHS burden; can affect assays | | MeCN (HPLC) | Volatile; compatible with LC | Flammable; toxicity and solvent waste |

Process considerations:

  • Optimize purification with aqueous RP‑HPLC gradients to limit solvent volumes and favor water-rich elution.
  • Implement miniaturized assays and concentrated stocks to reduce solvent waste.
  • Capture and recycle acetonitrile where infrastructure allows.

Note: These are general green-chemistry practices for peptides and are not item-specific specifications.

Pharmaceutical Uses

No therapeutic claims. This research reagent is not intended for human or veterinary use.

Relevant formulation/CMC contexts (general, non‑clinical):

  • Reference standard: May be used as a system suitability or calibration standard in peptide analytical methods (e.g., LC‑UV/LC‑MS) supporting discovery workflows.
  • Process development: Model peptide for evaluating adsorption, leachables/extractables, or stability-indicating methods under manufacturing-like conditions.
  • Excipient compatibility screens: Assess interactions with buffers, tonicity agents (e.g., mannitol), surfactants (polysorbates), and antioxidants in preformulation studies.
  • Impurity profiling: Benchmark for oxidative (Met/Trp), deamidation (Asn/Gln), and backbone cleavage pathways under stress testing to validate stability-indicating methods.

Regulatory status:

  • No pharmacopeial monograph is implied. Any use as a standard in regulated environments requires in‑house qualification against traceable references.

Practical considerations:

  • Define the salt form/counter‑ion (e.g., acetate, TFA) and water content for mass balance when preparing standards.
  • Verify potency by mass assay and purity by HPLC/UPLC. Document storage and handling per quality system requirements.
Physical Properties

Item-specific physico-chemical specifications are not provided in the product data.

  • Appearance: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Weight (MW): Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Density/RI/BP/MP: Not applicable or not typically reported for peptides; consult CoA if measured.

General/literature expectations for GLP‑1(9–36)-type peptides (for planning only):

  • Physical state: Solid (lyophilized powder or film) at ambient conditions; readily forms clear solutions upon dissolution in aqueous buffers.
  • Solubility: Highly soluble in water and physiological buffers; initial wetting with a small volume of water or dilute acid (e.g., 0.1% TFA or HCl) can aid dissolution before dilution. Co-solubilization in a minimal volume of DMSO may be used for hydrophobic variants.
  • pH stability: Peptides are generally most stable when stored as aliquots at acidic pH (≈pH 4–6) and low temperature; sequence dependent (literature). Avoid repeated freeze–thaw.
  • Charge/Isoelectric behavior: Contains acidic and basic residues; overall net charge is pH-dependent, promoting aqueous solubility near neutral pH (literature).

Important:

  • Do not treat the above as specifications. If you require exact values (e.g., counter‑ion content, residual solvents, water content), use the lot-specific Certificate of Analysis (CoA) or Specification Sheet.
Quality and Grades
  • Supplied Grade: Moligand™

What this generally implies:

  • Intended use: Discovery chemistry and ligand screening workflows in which consistency, identity, and fitness for biochemical assays are prioritized.
  • Purity & analytical controls: Numerical purity, counter‑ion content, water/ash, residual solvents, and peptide-related impurities are lot‑specific. Not specified for this item; refer to CoA/Spec Sheet.
  • Identity confirmation: Typically supported by MS and, where appropriate, HPLC/UPLC and amino acid analysis in peptide-grade materials (general practice). Confirm per CoA.

Practical notes for this item:

  • If your application requires defined salt form (e.g., acetate vs TFA), endotoxin limits, or peptide mapping, request the lot CoA/Spec Sheet prior to use.
  • For quantitative studies, verify concentration post‑reconstitution by UV at 280 nm when aromatic residues are present, or by amino acid analysis; extinction coefficients are sequence-dependent (literature; not item-specific).

Comparison of common research grades (general guidance):

  • Screening/Ligand grade: Suitable for high-throughput screening and biochemical assays; QC emphasizes identity and functional use.
  • Analytical/Reference grade: Enhanced documentation for analytical method development.

Bottom line: Treat Moligand™ as a research‑grade peptide for screening and method development. Defer to the item’s CoA for all numerical specifications.

Reaction and Applications

This peptide is primarily used as a research tool in biochemistry and analytical science rather than as a substrate for classical organic reactions. Typical laboratory applications include:

  • Biochemical probing (literature): GLP‑1(9–36) is a well-known metabolite fragment of GLP‑1 generated by DPP‑4. It is used to differentiate receptor‑dependent vs fragment‑dependent readouts in vitro. No medical/clinical claims.
  • Analytical standards: Method development for LC/LC‑MS peptide mapping, retention time indexing, and assay calibration.
  • Conjugation chemistry: Installation of labels/handles on lysine side chains or N‑terminus using NHS esters, isothiocyanates, aldehyde/oxime ligations, maleimide tags (if Cys present; check sequence), or click handles after azide/alkyne introduction.
  • Surface immobilization: Amine-coupling to carboxylated chips (SPR/BLI) via EDC/NHS; adsorption minimization via carrier proteins or surfactants.
  • Proteolysis studies: Benchmarking susceptibility to DPP‑4 and other proteases; mapping cleavage patterns.

Practical tips:

  • Work at low micromolar concentrations to reduce self‑association; include 0.01–0.05% non‑ionic surfactant if nonspecific adsorption is problematic (assay‑dependent).
  • For conjugations, adjust to pH 7.5–8.5 (amine-reactive chemistries) or pH 4.5–6 (carbodiimide to amines via activated esters). Remove excess reagents by spin desalting or RP cleanup.
  • Validate integrity by LC‑MS before and after any chemical modification.
Reaction Conditions

As a peptide reagent, typical “reactions” involve bioconjugation or analytical sample preparation rather than small‑molecule transformations. General conditions (literature guidance):

  • Amine-targeted labeling (NHS esters):
    • Buffer: 50–100 mM phosphate or HEPES, pH 7.5–8.5 (amine unprotonated).
    • Stoichiometry: 2–10 equiv reagent per accessible amine.
    • Temperature/time: RT, 15–120 min; protect from moisture.
    • Quench: Tris or glycine; purify by RP‑HPLC or desalting.
  • EDC/sulfo‑NHS coupling (carboxylates → amide):
    • Buffer: 50 mM MES, pH 4.7–6.0 (stabilizes O‑acylisourea/NHS ester).
    • Reagents: 5–20 equiv EDC, 5–20 equiv sulfo‑NHS vs carboxylate.
    • Time: 15–60 min activation + 30–120 min coupling at RT.
  • Azide/alkyne click (CuAAC):
    • Buffer: PBS with 10–20% t‑BuOH or DMSO if needed.
    • Catalyst: CuSO4 (0.1–1 mM) + sodium ascorbate; ligand (THPTA) to minimize peptide oxidation.
    • Time: 15–60 min at RT; remove copper post‑reaction via chelators or RP cleanup.
  • Oxidation sensitivity controls: Include antioxidants (e.g., 0.1–1 mM methionine) if Met/Trp present; avoid light and air for long incubations.

Yields: Highly sequence- and reagent-dependent; assess conversion by LC‑MS. Always verify the exact sequence/termini on the CoA before selecting conditions.

Safety and Handling
  • GHS Classification: Not specified for this item; refer to SDS.
  • Signal Word / H‑Statements / Pictograms: Not specified for this item; refer to SDS.
  • Research Use: For research use only. Not for human or veterinary use.

General laboratory precautions for peptides and biomolecules:

  • PPE: Lab coat, safety glasses, and suitable gloves (e.g., nitrile). Avoid inhalation of powders and contact with skin/eyes.
  • Handling: Open vials in a clean, dry environment. Minimize aerosol formation. For hygroscopic materials, allow to equilibrate to room temperature before opening to prevent condensation.
  • First aid (overview):
    • Skin/eye contact: Rinse with water for several minutes; remove contaminated clothing; seek medical advice if irritation persists.
    • Inhalation: Move to fresh air; obtain medical attention if symptoms occur.
    • Ingestion: Rinse mouth; seek medical advice.
  • Incompatibilities: Strong oxidizers and proteolytic enzymes; avoid high pH and elevated temperatures that can promote deamidation/oxidation (general peptide guidance).
  • Spill response: Gently dampen to avoid dusting, wipe with absorbent, and dispose according to institutional guidelines.
  • Waste disposal: Follow local regulations for peptide/biological chemical waste; do not discharge to drains.

Always consult the product’s Safety Data Sheet (SDS) for authoritative hazard classifications and emergency measures.

Solvent Selection

GLP‑1‑type peptides are polar and typically dissolve in aqueous media. Optimal solvent choice depends on the specific sequence, counter‑ion, and desired application.

  • Primary solvents (recommended):
    • Water, PBS, HEPES, or acetate buffer (pH 4–7): Promote solubility and stability; choose low‑ionic strength for stock solutions to minimize aggregation.
    • Dilute acid (e.g., 0.1% TFA or HCl): Useful as a wetting step for rapid dissolution before buffering to final pH.
  • Co‑solvents (as needed):
    • DMSO (analytical grade): For highly hydrophobic variants; keep final DMSO ≤10% v/v in assays to preserve biological systems and avoid peptide aggregation (general guidance).
    • Acetonitrile/water mixes: Common for LC applications and preparative work.
  • Avoid/Use caution: Strong bases (promote deamidation/racemization), oxidizing agents (Met/Trp oxidation), and high organic content that may induce precipitation upon dilution.

Small comparison (general):

  • Water/buffer: maximal compatibility with bioassays; best first choice.
  • DMSO: powerful co‑solvent for stocks; may impact assay readouts.
  • MeCN: LC compatibility; less suitable for long‑term storage.

Tip: Prepare a small‑volume concentrated stock in suitable solvent, then dilute into assay/buffer immediately prior to use to limit adsorption and degradation.

Storage and Reconstitution
  • Storage Conditions (as provided): Room temperature.
  • Shipped In: Not specified for this item; refer to CoA/Spec Sheet.

General best practices for peptide stability (not item-specific; defer to label if different):

  • If long-term storage is required after opening or reconstitution, aliquot and store at low temperature (e.g., −20 to −80 °C) to minimize degradation and microbial growth. Avoid repeated freeze–thaw cycles.
  • Protect from light, moisture, and air exposure. Allow lyophilized material to equilibrate to room temperature before opening to prevent condensation.

Reconstitution guidance (general):

  • Use sterile, low‑binding plasticware. Dissolve initially in water or mildly acidic buffer; adjust to final buffer and concentration. Filter (0.22 µm) if sterility is required.
  • Record the exact solvent, pH, and concentration. For quantitative work, verify concentration by UV (if aromatic residues present) or amino acid analysis.

Stability notes:

  • Sequence‑dependent degradation pathways include oxidation (Met/Trp), deamidation (Asn/Gln), and backbone cleavage at elevated pH/temperature (literature). Work promptly at the lowest feasible temperature.

Always prioritize the storage instructions on the product label/CoA for this specific item.

Structure and Identity

A peptide fragment corresponding to residues 9–36 of human GLP‑1, widely used as a biochemical research tool and peptide chemistry reference.

  • Product Name: GLP-1-(9-36)
  • SKU: rp174138
  • CAS: rp174138 (catalog placeholder; not a registered CAS)
  • InChIKey: 404681 (as provided; note this is not a standard peptide InChIKey)
  • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.

Structural features (general/literature):

  • Chemical class: Linear peptide (approx. 28 amino acids when human-sequence derived).
  • Backbone: Repeating –NH–CHR–CO– units with side-chain functionalities (acidic, basic, polar, hydrophobic) typical of GLP‑1 fragments.
  • Termini: N‑terminus free amine and C‑terminus commonly amidated in native human GLP‑1 fragments (literature); check item CoA for exact termini.
  • Secondary structure propensity: Predominantly random coil in aqueous solution with transient helical segments (literature), sequence- and solvent-dependent.

2D description in words (literature-based):

  • A single, unbranched polypeptide chain containing a mixture of polar (Ser, Thr, Gln), acidic (Glu/Asp), basic (Lys/Arg), and hydrophobic residues (Leu, Val, Ile, Phe, Trp), lacking disulfide bonds. No stereochemical ambiguity—standard L‑amino acids unless specified otherwise on the CoA.

Notes:

  • Exact sequence, post‑translational modifications, and peptide counter‑ions/salt form are item-specific; please consult the product CoA/Spec Sheet for definitive identity attributes.
Synthetic Utility

Although supplied as a finished peptide, GLP‑1(9–36) can serve as a versatile scaffold for chemical derivatization and method development.

  • Conjugation handles:
    • N‑terminus / Lys ε‑amines: Acylation (NHS esters), isothiocyanate labeling, sulfo‑NHS coupling for aqueous bioconjugation.
    • Carboxylates (Asp/Glu, C‑terminus if not amidated): EDC/sulfo‑NHS activation to amine-bearing partners.
    • Aromatic residues (Tyr/Trp/Phe): Electrophilic labeling (e.g., diazonium coupling for Tyr) with caution; confirm sequence.
  • Click-ready modifications: Introduce azide/alkyne tags via NHS‑azide/alkyne reagents on Lys or N‑terminus, enabling CuAAC or SPAAC ligations to probes, polymers, or surfaces.
  • PEGylation/lipidation: Site‑selective modification for solubility or membrane interaction studies; evaluate impact on assay readouts.
  • Isotopic labeling: 13C/15N/Ala‑scan or residue‑specific labels to facilitate MS quantitation and structural probing.

Analytical method development:

  • Use as a test article for optimizing RP‑HPLC gradients, ion‑pairing systems, and MS source conditions (ESI+, multiple charge states). Track sequence‑dependent degradation (deamidation, oxidation) to qualify stability‑indicating assays.

Note: Exact reactive residue content is sequence‑dependent. Consult the item CoA/Spec Sheet for the definitive amino acid sequence and termini before planning site‑selective chemistry.

Target Specificity

No target or application specificity is provided for this catalog item.

  • Item-specific antigen/epitope, receptor binding data, clone/isotype, or species reactivity: Not specified for this item; refer to CoA/Spec Sheet.

General literature context:

  • GLP‑1(9–36) is commonly used as a peptide control or comparator in studies of incretin biology. However, no target specificity claims are made for this product entry.

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