GLPG2451 - 10mM in DMSO , CAS No.2055015-61-5

CAS: 2055015-61-5 Cat. No.: G654975 Molecular Weight: 419.38 PubChem CID: 124106089

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC 50 of 11.1 nM

In Vitro

GLPG2451 has an EC 50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Cystic fibrosis transmembrane conductance regulator

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC 50 of 11.1 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Names and Identifiers

• Isomeric SMILES: C[C@@H](CNC(=O)C1=C(C=C(C=N1)S(=O)(=O)C2=CC=C(C=C2)OC(F)(F)F)N)O
• Alternate CAS: 2055015-61-5
• PubChem CID: 124106089
• Molecular Weight: 419.38

Associated Targets(Human)

CFTR Tclin Cystic fibrosis transmembrane conductance regulator (2 Activities)

Discover Target: CFTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)