GNF179 - 10mM in DMSO , CAS No.1261114-01-5

CAS: 1261114-01-5 Cat. No.: G654993 Formula: C₂₂H₂₃ClFN₅O Peso molecolare: 427.90

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency ( IC 50 of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally active

In Vitro

GNF179 does not rapidly inhibit parasite protein biosynthesis nor is it likely to target parasite cytochrome bc1, which has been validated as a hepatic stage target for Atovaquone . GNF179 may act against sporozoites instead of hepatic stages. GNF179 (5-100 nM; 48 h) shows high inhibition of gametocyte sexual life cycle progression in the mosquito as it abolished oocyst formation at 5 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GNF179 (15 mg/kg; p.o.; single dose) shows antimalarial activity in rodent malaria model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Naïve Balb/C mice infected with P. berghei Dosage: 15 mg/kg Administration: Oral, single dose Result: Protected against an infectious P. berghei sporozoite. Animal Model: Naïve Balb/C mice Dosage: 3 or 20 mg/kg Administration: IV or PO (Pharmacokinetic Analysis) Result: Pharmacokinetics of GNF179 in naïve Balb/C mice . Dose AUC (0-∞) (hrs*µM) AUC/dose t 1/2 (hrs) MRT (hrs) CL (ml/min/kg) V ss (L/kg) C 0 or C max (µM) F (%) 3 mg/kg i.v. 8.88 3.0 8.9 9.0 22 11.8 6.1 nd 20 mg/kg p.o. 20.70 1.0 8.4 nd nd nd 1.2 58 AUC, Area Under the Curve; T 1/2 , half life; CL, clearance; V SS , steady-state volume of distribution; C 0 , initial concentration; C max maximum concentration; F, fraction of dose absorbed; hrs, hours; nd, not determined.

IC50& Target:Plasmodium

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency ( IC 50 of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally active.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Nomi e identificatori

• Peso molecolare: 427.90

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1261114-01-5, the molecular formula is C22H23ClFN5O, and the molecular weight is 427.90 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.