GW-6604 - ≥98% , CAS No.452342-37-9

CAS: 452342-37-9 Cat. No.: G646467 Formula: C₁₉H₁₄N₄ Peso molecolare: 298.34 PubChem CID: 9861063

GRADE & PURITY ≥98%

Synonyms

GW6604;GW 6604 | SCHEMBL154508 | UNII-273G6SN31H | Pyridine, 2-phenyl-4-(3-(2-pyridinyl)-1H-pyrazol-4-yl)- | 2-Phenyl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine | 2-phenyl-4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridine | Q27254160 | BDBM50184881 | EX-A6727

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

GW-6604 is an ALK5 inhibitor with an IC 50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis.

In Vitro

GW-6604 (0-10 μM, ) inhibits TGF-β-induced PAI-1 transcription and secretion in HepG2 cells with an IC 50 value of 500 nM, effectively blocking the Smad-dependent response. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GW-6604(p.o., 25-80 mg/kg, twice a day, 3 weeks) dependently inhibits hepatic COL IA1 overexpression in an acute DMN model in SD rats, reducing its expression by 80%. Normal liver weight was maintained, liver fibrosis was effectively reduced and matrix degeneration was increased . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Sinonimi

GW6604;GW 6604 | SCHEMBL154508 | UNII-273G6SN31H | Pyridine, 2-phenyl-4-(3-(2-pyridinyl)-1H-pyrazol-4-yl)- | 2-Phenyl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine | 2-phenyl-4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridine | Q27254160 | BDBM50184881 | EX-A6727

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

GW-6604 is an ALK5 inhibitor with an IC 50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis.

Condizioni di conservazione di stoccaggio

Protected from light,Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Purezza

≥98%

Nomi e identificatori

• Sorrisi canonici: C1=CC=C(C=C1)C2=NC=CC(=C2)C3=C(NN=C3)C4=CC=CC=N4
• IUPAC Name: 2-phenyl-4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridine
• InChIKey: BDCBRQYHYNUWAM-UHFFFAOYSA-N
• INCHI: 1S/C19H14N4/c1-2-6-14(7-3-1)18-12-15(9-11-21-18)16-13-22-23-19(16)17-8-4-5-10-20-17/h1-13H,(H,22,23)
• Isomeri SMILES: C1=CC=C(C=C1)C2=NC=CC(=C2)C3=C(NN=C3)C4=CC=CC=N4
• CAS alternativo: 452342-37-9
• PubChem CID: 9861063
• Termini MeSH: 2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine;GW 6604;GW-6604;GW6604
• Peso molecolare: 298.34

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Pyridines and derivatives
      • Subclass Phenylpyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Pyridines and derivatives
• Subclass: Phenylpyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyridines
• Alternative Parents: Benzene and substituted derivatives Pyrazoles Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: 2-phenylpyridine - Benzenoid - Monocyclic benzene moiety - Heteroaromatic compound - Pyrazole - Azole - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

TGFBR1 Tchem TGF-beta receptor type I (3786 Activities)

Discover Target: TGFBR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACVR1B Tchem Activin receptor type-1B (1131 Activities)

Discover Target: ACVR1B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsomes (16955 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Obiettivi associati (non umani)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Sensibilità: light sensitive
• Peso molecolare: 298.300 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 298.122 Da
• Monoisotopic Mass: 298.122 Da
• Topological Polar Surface Area: 54.500 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 368.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Domande frequenti

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 452342-37-9, the molecular formula is C19H14N4, and the molecular weight is 298.34 g/mol. InChIKey BDCBRQYHYNUWAM-UHFFFAOYSA-N.

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.