GW6471 - 10mM in DMSO , Antagonist of Peroxisome proliferator-activated receptor-α, CAS No.880635-03-0, Antagonist of Peroxisome proliferator-activated receptor-α

CAS: 880635-03-0 Cat. No.: G426654 Formula: C₃₅H₃₆F₃N₃O₄ Peso molecolare: 619.67 Numero EC: 804-305-7

GRADE & PURITY 10mM in DMSO

Synonyms

GTPL3440 | MLS006010816 | NCGC00165799-01 | SCHEMBL15153020 | N-[(2S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-[[(Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl]amino]propyl]propanamide | Propanamide, N-((2S)-2-(((1Z)-1-methyl-3-ox

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

GW6471 is a PPARα antagonist, shown to completely inhibit GW409544-induced activation of PPARα. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.

Specifications

Sinonimi

GTPL3440 | MLS006010816 | NCGC00165799-01 | SCHEMBL15153020 | N-[(2S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-[[(Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl]amino]propyl]propanamide | Propanamide, N-((2S)-2-(((1Z)-1-methyl-3-ox

Specifiche e purezza

10mM in DMSO

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Tipo di azione

ANTAGONIST

Meccanismo d'azione

Antagonist of Peroxisome proliferator-activated receptor-α

Nomi e identificatori

• Pubchem Sid: 528764718
• Sorrisi canonici: CCC(=O)NCC(CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)NC(=CC(=O)C4=CC=C(C=C4)C(F)(F)F)C
• IUPAC Name: N-[(2S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-[[(Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl]amino]propyl]propanamide
• InChIKey: TYEFSRMOUXWTDN-DYQICHDWSA-N
• INCHI: 1S/C35H36F3N3O4/c1-4-33(43)39-22-29(40-23(2)20-32(42)26-12-14-28(15-13-26)35(36,37)38)21-25-10-16-30(17-11-25)44-19-18-31-24(3)45-34(41-31)27-8-6-5-7-9-27/h5-17,20,29,40H,4,18-19,21-22H2,1-3H3,(H,39,43)/b23-20-/t29-/m0/s1
• Isomeri SMILES: CCC(=O)NC[C@H](CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)N/C(=C\C(=O)C4=CC=C(C=C4)C(F)(F)F)/C
• WGK Germania: 3
• CAS alternativo: 436159-64-7
• Peso molecolare: 619.67
• Reaxy-Rn: 31837484
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31837484&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Azoles
      • Subclass Oxazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Azoles
• Subclass: Oxazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenyl-1,3-oxazoles
• Alternative Parents: Trifluoromethylbenzenes Amphetamines and derivatives 2,4,5-trisubstituted oxazoles Phenoxy compounds Phenol ethers Aryl ketones Benzoyl derivatives Alkyl aryl ethers Aralkylamines Vinylogous amides Acryloyl compounds Enones Heteroaromatic compounds Amino acids and derivatives Secondary carboxylic acid amides Dialkylamines Azacyclic compounds Oxacyclic compounds Enamines Organic oxides Organofluorides Organopnictogen compounds Alkyl fluorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenyl-1,3-oxazole - Amphetamine or derivatives - Trifluoromethylbenzene - Phenol ether - Aryl ketone - Benzoyl - 2,4,5-trisubstituted 1,3-oxazole - Phenoxy compound - Aralkylamine - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Vinylogous amide - Alpha,beta-unsaturated ketone - Enone - Acryloyl-group - Ketone - Carboxamide group - Amino acid or derivatives - Secondary carboxylic acid amide - Oxacycle - Azacycle - Secondary amine - Carboxylic acid derivative - Secondary aliphatic amine - Enamine - Ether - Alkyl fluoride - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Alkyl halide - Amine - Organooxygen compound - Organic oxide - Organonitrogen compound - Organohalogen compound - Organofluoride - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as phenyl-1,3-oxazoles. These are aromatic heterocyclic compounds containing a 1,3-oxazole substituted at one or more positions by a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

PPARA Tclin Peroxisome proliferator-activated receptor alpha (0 Activities)

Discover Target: PPARA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Peso molecolare: 619.700 g/mol
• XLogP3: 7.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 14
• Exact Mass: 619.266 Da
• Monoisotopic Mass: 619.266 Da
• Topological Polar Surface Area: 93.500 Ų
• Heavy Atom Count: 45
• Formal Charge: 0
• Complexity: 954.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Riferimenti

1. Yuhang Li, Yitian Li, Sennan Xu, Yue Chen, Pan Zhou, Ting Hu, Hua Li, Ying Liu, Yaping Xu, Jie Ren, Yan Qiu, Canzhong Lu.  (2022)  N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation.  PHARMACOLOGICAL RESEARCH,      [PMID:36244543] [10.1016/j.phrs.2022.106491]

2. Hongyi Xian, Ruobing Bai, Yu Feng, Shiyue Tang, Zhiming Li, Chudan Gao, Kaiwei Li, Boxuan Liang, Yizhou Zhong, Yuji Huang, Hao Li, Yanhong Deng, Xiaohong Yang, Xiyun Huang, Xiaoqing Chen, Xingfen Yang, Zhenlie Huang.  (2025)  Aged polylactic acid microplastics exacerbate lipid metabolism disorders and cardiac dysfunction via PPARγ activation in zebrafish: A comparative study with polymers and oligomers.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:41187537] [10.1016/j.ecoenv.2025.119337]

3. Yan Jin, Fang Lu, Xi Miaocui, Liu Ziqi, Zhang Shihan, Zhang Yuning, Zhang Yuwei, Xue Ting, Li Jiahang, Huang Yue, Chang Runfeng, Qian Qiuhui, Wang Zejun, Teng Miaomiao, Wang Huili.  (2026)  Ethylhexyl Diphenyl Phosphate Mediates Oxidative Stress and Energy Metabolism Abnormalities by Affecting Glycolipid Metabolism in Zebrafish during Early Development: Key Regulatory Role of the Peroxisome Proliferator-Activated Receptor Signaling Pathway.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  60  (30): (20740-20756).  [PMID:42482340] [10.1021/acs.est.5c06517]