H1PVAT - ≥95% , CAS No.351438-49-8

CAS: 351438-49-8 Cat. No.: H646813 Molecular Weight: 417.41

GRADE & PURITY ≥95%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

H1PVAT is a potent and selective inhibitor of poliovirus serotypes (PV-1, PV-2, PV-3), and inhibits early stage of the replication. H1PVAT interacts with viral capsid directly and protects PV against heat inactivation

In Vitro

H1PVAT (10-218 nM; 24-48 h) inhibits poliovirus strain Sabin replication in a dose-dependent manner, with EC 50 s of 10 nM (PV-1), 26 nM (PV-2) and 218 nM (PV-3), respectively. H1PVAT (30 min prior to or 1 h after PV-1 infection; 7 h) inhibits an early stage of viral replication , and only H1PVAT is administered prior to infection results reduction (>99.9%) in intracellular viral RNA levels. H1PVAT (50 μM; 2 min) protects PV against heat inactivation with the 50% thermal inactivation temperature increased to 52.6 ℃ and 50.8 ℃, which suggests a direct interaction between the viral capsid and H1PVAT. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:EC50: 10 nM (PV-1), 26 nM (PV-2), 218 nM (PV-3)

Specifications

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

H1PVAT is a potent and selective inhibitor of poliovirus serotypes (PV-1, PV-2, PV-3), and inhibits early stage of the replication. H1PVAT interacts with viral capsid directly and protects PV against heat inactivation.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Canonical Smiles: O=C(C1=NN2C(C(F)(F)F)CC(C3=CC=CS3)NC2=C1)NC4=CC=C(C#N)C=C4
• Molecular Weight: 417.41