HA14-1 - 10mM in DMSO , CAS No.65673-63-4

CAS: 65673-63-4 Cat. No.: H408968 Formula: C₁₇H₁₇BrN₂O₅ Peso molecolare: 409.23

GRADE & PURITY 10mM in DMSO

Synonyms

(R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

HA14-1 is a non-peptidic ligand of aBcl-2surface pocket withIC50of ~9 μM.
In vitro

HA14-1 is a small molecule and nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of approximately 9 μM. HA14-1 induces the apoptosis of HL-60 cells in a dose-dependent manner via caspase activation. HA14-1 shows cytotoxic effects on HF1A3, HF4.9 and HF28RA follicular lymphoma B cell lines with LC50 of 4.5 μM, 12.6 μM and 8.1 μM respectively. HA14-1 induces apoptosis of HF1A3, HF4.9 and HF28RA cells via caspase and ROS.

In vivo

HA14-1(400 nM) treatment did not have any significant effect on the growth of glioblastoma tumors in immunodeficient mice. But HA14-1 (400 nM) increases the effect of the DNA-damaging agent etoposide (2.5 mg/Kg) on glioblastoma growth in vivo.
Cell Data

cell lines：

Concentrations：~25 μM

Incubation Time：20 h

Powder Purity:

Specifications

Sinonimi

(R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Nomi e identificatori

• Isomeri SMILES: CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N
• WGK Germania: 3
• Peso molecolare: 409.23
• Reaxy-Rn: 1405035
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1405035&ln=

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 32.5 mg/mL warmed with 50ºC Water: bath (100.16 mM); Water: Insoluble; Ethanol: Insoluble
• Indice di rifrazione: 1.57
• Punto di ebollizione (°C): 535.1° C at 760 mmHg
• Punto di fusione (°C): 105-108°C

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 65673-63-4, the molecular formula is C17H17BrN2O5, and the molecular weight is 409.23 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.