HBX 41108 - ≥98%(HPLC) , CAS No.924296-39-9

CAS: 924296-39-9 Cat. No.: H288426 Formula: C₁₃H₃ClN₄O Peso molecolare: 266.64

GRADE & PURITY ≥98%(HPLC)

Synonyms

7-CHLORO-9-OXOINDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE | HBX 41108 | 9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 7-chloro-9-oxo- | A903088 | HY-101666 | SCHEMBL1512560 | C7JH7KSP8Z | HBX41108; HBX-41108; HBX 41,108; HBX-41,108; HBX41,108 | 7-Chloro-9-oxo

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Sinonimi

7-CHLORO-9-OXOINDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE | HBX 41108 | 9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 7-chloro-9-oxo- | A903088 | HY-101666 | SCHEMBL1512560 | C7JH7KSP8Z | HBX41108; HBX-41108; HBX 41,108; HBX-41,108; HBX41,108 | 7-Chloro-9-oxo

Specifiche e purezza

≥98%(HPLC)

Meccanismi biochimici e fisiologici

Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50= 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50= 0.8μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Purezza

≥98%(HPLC)

Nomi e identificatori

• Pubchem Sid: 504768021
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768021
• Sorrisi canonici: C1=CC2=C(C=C1Cl)C(=O)C3=NC(=C(N=C23)C#N)C#N
• IUPAC Name: 7-chloro-9-oxoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
• InChIKey: BIGPXXAUSQLTQR-UHFFFAOYSA-N
• INCHI: 1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
• Isomeri SMILES: C1=CC2=C(C=C1Cl)C(=O)C3=NC(=C(N=C23)C#N)C#N
• Peso molecolare: 266.64
• Reaxy-Rn: 12774588
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=12774588&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Classe Organooxygen compounds
      • Subclass Carbonyl compounds
        • Level5 Ketones
          • Level6 Aryl ketones

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Classe: Organooxygen compounds
• Subclass: Carbonyl compounds
• Intermediate Tree Nodes: Ketones
• Direct Parent: Aryl ketones
• Alternative Parents: Pyrazines Benzenoids Aryl chlorides Heteroaromatic compounds Nitriles Azacyclic compounds Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Aryl ketone - Aryl chloride - Aryl halide - Pyrazine - Benzenoid - Heteroaromatic compound - Organoheterocyclic compound - Nitrile - Carbonitrile - Azacycle - Hydrocarbon derivative - Organic oxide - Organonitrogen compound - Organochloride - Organohalogen compound - Cyanide - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as aryl ketones. These are organic aromatic compounds that contain a ketone group substituted at one C-atom with an aryl group. They have the generic structure RC(=O)R', where R = aryl group and R'=organyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (2 Activities)

Discover Target: USP7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP8 Tchem Ubiquitin carboxyl-terminal hydrolase 8 (1 Activities)

Discover Target: USP8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (837 Activities)

Discover Target: USP7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP47 Tchem Ubiquitin carboxyl-terminal hydrolase 47 (99 Activities)

Discover Target: USP47

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Solvent:DMSO, Max Conc. mg/mL: 26.66, Max Conc. mM: 100
• Sensibilità: Moisture sensitive
• Peso molecolare: 266.640 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 266 Da
• Monoisotopic Mass: 266 Da
• Topological Polar Surface Area: 90.400 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 503.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1