HC-030031 - Moligand™, 10mM in DMSO , Gating inhibitor of TRPA1, CAS No.349085-38-7, Gating inhibitor of TRPA1

CAS: 349085-38-7 Cat. No.: H408813 Formula: C₁₈H₂₁N₅O₃ Peso molecolare: 355.39 Numero EC: 631-548-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

TOSLAB 829227 | 7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

HC-030031 HC-030031 (TOSLAB 829227) is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.
In vitro

HC-030031 is a substituted theophylline derivative. Potent and selective TRPA1 inhibitor. HC-030031 can block both inward and outward currents elicited by AITC or formalin rapidly and reversibly and also blocks the activation of TRPA1 by N-methylmaleimide and by electrophillic prostaglandins. It does not block currents mediated by TRPV1, TRPV3, TRPV4 hERG, or NaV1.2 channels.

In vivo

HC-030031 can be delivered to animals orally, by inhalation, or by injection. Oral administration (100 mg/kg) of HC-030031 significantly reversed mechanical hypersensitivity in rat models of chronic inflammatory or neuropathic pain, while local injection (100 μg) into inflamed mouse hind paws attenuated mechanical, but not heat, hypersensitivity. ^{[2] [3]}
Cell Data

cell lines：KB3-1, KBV-1, Hela, and Hs578T cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

TOSLAB 829227 | 7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

HC-030031 (TOSLAB 829227) is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

GATING INHIBITOR

Meccanismo d'azione

Gating inhibitor of TRPA1

Nomi e identificatori

• Isomeri SMILES: CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C
• WGK Germania: 3
• Peso molecolare: 355.39
• Reaxy-Rn: 12759009
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=12759009&ln=

Obiettivi associati (umani)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (11 Activities)

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Indice di rifrazione: 1.65
• Punto di ebollizione (°C): 650.65° C
• Punto di fusione (°C): 221-223°C

Riferimenti

1. Jingyun Ding, Huiyan Wang, Zequn Li, Jiangnan Sun, Peng Ding, Xiaomei Chi, Mingfang Yang, Yaqing Chang, Chong Zhao.  (2022)  Digestive Enzyme Activities and Gut Emptying Are Correlated with the Reciprocal Regulation of TRPA1 Ion Channel and Serotonin in the Gut of the Sea Urchin Strongylocentrotus intermedius.  Biology-Basel,  11  (4): (503).  [PMID:35453703] [10.3390/biology11040503]

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 349085-38-7, the molecular formula is C18H21N5O3, and the molecular weight is 355.39 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.