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HeE1-2Tyr - 10mM in DMSO , CAS No.2245195-67-7
Disponibile su ordine
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile , Dengue and SARS-CoV-2 RdRps ( IC 50 of 27.6 µM) activity in vitro
In Vitro
HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC 50 of 2.1 µM, as well as all the four Dengue virus (DENV) serotypes, with IC 50 ranging from 6.8 to 15 µM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 µM. Additionally, upon infection of human HEK 293 cells (CC 50 of 50 µM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC 50 values ranging from 3.9 to 12 µM. HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:Flavivirus RNA dependent RNA polymerases (RdRp), SARS-CoV-2 RdRps>
Specifications
Specifiche e purezza
10mM in DMSO
Meccanismi biochimici e fisiologici
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile , Dengue and SARS-CoV-2 RdRps ( IC 50 of 27.6 µM) activity in vitro.
Condizioni di conservazione di stoccaggio
Store at -80°C
Spedito in
Dry ice packs + Cold packs
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Tipo di azione
INHIBITOR
Nomi e identificatori
| Peso molecolare | 582.67 |
|---|
Documentazione
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
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What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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