HPN-01 - 10mM in DMSO , CAS No.928655-63-4

CAS: 928655-63-4 Cat. No.: H655642 Formula: C₁₉H₁₆ClN₃O₃S Peso molecolare: 401.87 PubChem CID: 15979284

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

HPN-01 is a potent and selective IKK inhibitor, with pIC 50 values of 6.4, 7.0 and <4.8 for IKK-α , IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5 , CDK-2, EGFR , ErbB2, GSK3β, PLK1 , Src , and VEGFR-2

In Vitro

HPN-01 effectively suppress LPS-stimulated secretion of TNF-α, IL-1β, and IL-6 from human PBMCs (pIC 50 =6.1, 6.4, and 5.7, respectively). HPN-01 also inhibits TNF-α-induced NF-κB nuclear translocation in human lung fibroblast cells (pIC 50 =5.7). HPN-01 inhibits the expression of SREBP-1and SREBP-2 in cultured primary human hepatocytes with IC 50 s of 1.71 μΜ and 3.43 μΜ, respectively. HPN-01 is being development for the treatment of nonalcoholic fatty liver disease (NAFLD). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IKK-α 6.4 (pIC 50 ) IKK-β 7.0 (pIC 50 ) IKK-ε <4.8 (pIC 50 )

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

HPN-01 is a potent and selective IKK inhibitor, with pIC 50 values of 6.4, 7.0 and <4.8 for IKK-α , IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5 , CDK-2, EGFR , ErbB2

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Nomi e identificatori

• Isomeri SMILES: C1=CC(=CC=C1C2=C(C(=CC(=C2)C3=CC=C(C=C3)Cl)C(=O)N)N)S(=O)(=O)N
• PubChem CID: 15979284
• Peso molecolare: 401.87

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 928655-63-4, the molecular formula is C19H16ClN3O3S, and the molecular weight is 401.87 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.