Hydralazine HCl - 2mM in Water , CAS No.304-20-1

CAS: 304-20-1 Cat. No.: H423147 Formula: C₈H₈N₄·HCl Peso molecolare: 196.64 Numero EC: 206-151-0

GRADE & PURITY 2mM in Water

Synonyms

HYDRALAZINE HYDROCHLORIDE|304-20-1|HYDRALAZINE HCL|Apresoline|1-Hydrazinophthalazine hydrochloride|1-Hydrazinylphthalazine hydrochloride|Aiselazine|Dralzine|Hyperazin|Hyperex|Lopress|Hydralazine chloride|Slow-Apresolin|Apresine|Rolazine|Hydralazine monohy

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Hydralazine HCl is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM.
An inhibitor of Dnmt, MAO-A/B, and amine oxidase.

Specifications

Sinonimi

HYDRALAZINE HYDROCHLORIDE | 304-20-1 | HYDRALAZINE HCL | Apresoline | 1-Hydrazinophthalazine hydrochloride | 1-Hydrazinylphthalazine hydrochloride | Aiselazine | Dralzine | Hyperazin | Hyperex | Lopress | Hydralazine chloride | Slow-Apresolin | Apresine | Rolazine | Hydralazine monohy

Specifiche e purezza

2mM in Water

Meccanismi biochimici e fisiologici

1-Hydrazinophthalazine Hydrochloride is a DNA methyltransferase (Dnmt) inhibitor which modulates epigenetic regulation of gene expression. 1-Hydrazinophthalazine Hydrochloride also acts as a non-selective MAO-A/B inhibitor and semicarbazide sensitive amin

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Pubchem Sid: 528754710
• Sorrisi canonici: C1=CC=C2C(=C1)C=NN=C2NN.Cl
• IUPAC Name: phthalazin-1-ylhydrazine;hydrochloride
• InChIKey: ZUXNZUWOTSUBMN-UHFFFAOYSA-N
• INCHI: 1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H
• Isomeri SMILES: C1=CC=C2C(=C1)C=NN=C2NN.Cl
• WGK Germania: 3
• RTECS: TH9000000
• Peso molecolare: 196.64
• Reaxy-Rn: 3568329
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3568329&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazanaphthalenes
      • Subclass Benzodiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phthalazines
• Alternative Parents: Pyridazines and derivatives Imidolactams Benzenoids Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives Hydrazines and derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phthalazine - Imidolactam - Benzenoid - Pyridazine - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Hydrazine derivative - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as phthalazines. These are compounds containing a phthalazine moiety, which consists of a benzene ring fused to a pyridazine, forming a 2,3-benzodiazine skeleton.
• External Descriptors: hydrochloride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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CYP1A2 Tchem Cytochrome P450 1A2 (0 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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MDH1 Tchem Malate dehydrogenase cytoplasmic (119 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Punto di fusione (°C): 273°C(dec.)(lit.)
• Peso molecolare: 196.640 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 196.052 Da
• Monoisotopic Mass: 196.052 Da
• Topological Polar Surface Area: 63.800 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 150.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Riferimenti

1. Xia Wang, Chenqian Zhou, Bingnan He, Baida Kong, Lai Wei, Rong Wang, Jiajia Lin, Yiyan Shao, Jianbo Zhu, Yuanxiang Jin, Zhengwei Fu.  (2019)  8:2 Fluorotelomer alcohol causes G1 cell cycle arrest and blocks granulocytic differentiation in HL-60 cells.  ENVIRONMENTAL TOXICOLOGY,  34  (5): (666-673).  [PMID:30794351] [10.1002/tox.22733]

2. Baida Kong, Xia Wang, Bingnan He, Lai Wei, Jianbo Zhu, Yuanxiang Jin, Zhengwei Fu.  (2018)  8:2 fluorotelomer alcohol inhibited proliferation and disturbed the expression of pro-inflammatory cytokines and antigen-presenting genes in murine macrophages.  CHEMOSPHERE,      [PMID:30558807] [10.1016/j.chemosphere.2018.12.091]

3. Zejian Kuang, Hongjun Luo, Hui Li, Yongyin Zhou, Zhexuan Lin, Wenhong Luo.  (2025)  Hydralazine Attenuates Lipopolysaccharide-Induced Murine Myocardial Dysfunction by Inhibition of Semicarbazide-Sensitive Amine Oxidase.  Antioxidants,  14  (12):   [PMID:41462702] [10.3390/antiox14121502]