≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Conservare a -20°C Ships Cassetta del ghiaccio + cuscini per il ghiaccio Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
IWP-2 è un inibitore dell'elaborazione e della secrezione di Wnt con un IC50 di 27 nM in un test libero da cellule, blocca selettivamente la palmitoilazione di Wnt mediata da Porcn, non influisce sulla Wnt/β-catenina in generale e non mostra alcun effetto sulle risposte cellulari stimolate da Wnt. Un inibitore della produzione di Wnt
Applicazione
IWP-2 è stato utilizzato per trattare le linee cellulari L-Wnt-3a e L-Wnt-5a, per dimostrarne l'effetto inibitorio. È stato inoltre utilizzato come inibitore della segnalazione Wnt per trattare cellule stromali WT e Gja1Jrt/+, per confermare che la via di segnalazione Wnt/β-catenina non era coinvolta nell'aumento dell'espressione dei marcatori da parte degli osteoblasti Gja1Jrt/+.
Inibitore dell'elaborazione e della secrezione di Wnt. Inattiva PORCN, una O-aciltransferasi legata alla membrana (MBOAT), e inibisce selettivamente la palmitoilazione di Wnt. Blocca la fosforilazione Wnt-dipendente del recettore Lrp6 e di Dvl2 e l'accumu
This compound belongs to the class of organic compounds known as thienopyrimidines. These are heterocyclic compounds containing a thiophene ring fused to a pyrimidine ring. Thiophene is 5-membered ring consisting of four carbon atoms and one sulfur atom. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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What is the purity of this product?
This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 686770-61-6, the molecular formula is C22H18N4O2S3, and the molecular weight is 466.6 g/mol. InChIKey WRKPZSMRWPJJDH-UHFFFAOYSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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