JDTic dihydrochloride - 10mM in DMSO , CAS No.785835-79-2

CAS: 785835-79-2 Cat. No.: J656525 Formula: C₂₈H₄₁Cl₂N₃O₃ Peso molecolare: 538.55 PubChem CID: 66576991

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR) , blocking the κ-agonist U50, 488-induced antinociception.

In Vivo

JDTic (2.5-16 mg/kg, s.c.) dose-dependently blocks the antinociceptive response of nicotine in the tail-flick test but has no effect in the hot-plate assay or body temperature assessments at any dose tested in the mice injected with nicotine . JDTic (3 mg/kg, i.p.) is capable of reversing anxiety-like behavior in the rat model of hangover anxiety. JDTic (10 mg/kg, i.p.) decreases alcohol self-administration, suppresses cue-induced reinstatement of alcohol seeking, and specifically blocks the effects of a KOR agonist at the 2 h pretreatment time point. JDTic (30 mg/kg, i.g.) significantly blockes U50,488-induced diuresis immediately in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR) , blocking the κ-agonist U50, 488-induced antinociception.

Condizioni di conservazione di stoccaggio

Desiccated,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

ANTAGONIST

Nomi e identificatori

• Isomeri SMILES: C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)C[C@H](C(C)C)NC(=O)[C@H]3CC4=C(CN3)C=C(C=C4)O.Cl.Cl
• CAS alternativo: 785835-79-2
• PubChem CID: 66576991
• Peso molecolare: 538.55

Domande frequenti

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 785835-79-2, the molecular formula is C28H41Cl2N3O3, and the molecular weight is 538.55 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.