JHU-083 - ≥99% , CAS No.1998725-11-3

CAS: 1998725-11-3 Cat. No.: J414248 Molecular Weight: 312.36

GRADE & PURITY ≥99%

Synonyms

Ethyl 2-(2-Amino-4-methylpentanamido)-DONL-​Norleucine,L-​leucyl-​6-​diazo-​5-​oxo-​,ethyl ester

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

JHU-083 JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b + cells and prevents depression-associated behaviors induced by chronic social defeat stress. Solutions are best fresh-prepared.

Targets

Glutaminase

In vitro

JHU-083 selectively inhibits T-cell proliferation and decreases T-cell activation, with no effect on DCs.

In vivo

orally administered JHU-083 significantly decreases the experimental autoimmune encephalomyelitis(EAE) severity in both prevention and treatment paradigms and reverses EAE-induced cognitive impairment.

Cell Research(from reference)

Cell lines：CD4⁺ T cells 

Concentrations：1 μM, 3 μM, 10 μM, 30 μM, or 100 μM 

Incubation Time：72h 

Specifications

Synonyms

Ethyl 2-(2-Amino-4-methylpentanamido)-DONL-​Norleucine, L-​leucyl-​6-​diazo-​5-​oxo-​, ethyl ester

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b⁺ cells and prevents depression-associated behaviors induced by chronic social defeat stress.Solutions a

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CCOC(=O)C(CCC(=O)C=[N+]=[N-])NC(=O)C(CC(C)C)N
• IUPAC Name: ethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-6-diazo-5-oxohexanoate
• InChIKey: YZRCHOFKIPHQBW-RYUDHWBXSA-N
• INCHI: 1S/C14H24N4O4/c1-4-22-14(21)12(6-5-10(19)8-17-16)18-13(20)11(15)7-9(2)3/h8-9,11-12H,4-7,15H2,1-3H3,(H,18,20)/t11-,12-/m0/s1
• Isomeric SMILES: CCOC(=O)[C@H](CCC(=O)C=[N+]=[N-])NC(=O)[C@H](CC(C)C)N
• Molecular Weight: 312.36
• Reaxy-Rn: 29866752
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29866752&ln=

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 62 mg/mL (198.48 mM); Water: 62 mg/mL (198.48 mM); Ethanol: 62 mg/mL (198.48 mM)