JHU395 - ≥98% , CAS No.2079938-92-2

CAS: 2079938-92-2 Cat. No.: J414249 Formula: C₂₂H₂₉N₃O₇ Peso molecolare: 447.48 PubChem CID: 126555751

GRADE & PURITY ≥98%

Synonyms

L-​Norleucine,6-​diazo-​N-​[[(2,​2-​dimethyl-​1-​oxopropoxy)​phenylmethoxy]​carbonyl]​-​5-​oxo-​,1-​methylethyl ester

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Information

JHU395 JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity.

Targets

Glutamine

In vitro

JHU395 inhibits growth of multiple biosynthetic processes by tumors (MPNST) cells, while growth of immortalized Schwann cells is minimally affected. JHU395 induces less PARP cleavage as a marker of apoptosis in human MPNST cells. JHU395 is a plasma stable lipophilic GA prodrug which delivers DON to MPNST in an in vitro plasma to tumor cell partitioning assay measurement.

In vivo

orally administered JHU395 delivers active GA to tumors with over twofold higher tumor-to-plasma exposure, and significantly inhibits tumor growth in a murine flank MPNST model without observed toxicity.

Cell Research(from reference)

Cell lines：sNF96.2, sNF02.2, ipn02.32 

Concentrations：10 μM, 20μM 

Incubation Time：1 h, 24 h 

Specifications

Sinonimi

L-​Norleucine,6-​diazo-​N-​[[(2,​2-​dimethyl-​1-​oxopropoxy)​phenylmethoxy]​carbonyl]​-​5-​oxo-​,1-​methylethyl ester

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and sig

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥98%

Proprietà del prodotto

• ALogP: 4.148
• Conteggio HBD: 1
• Legame rotabile: 14

Nomi e identificatori

• Sorrisi canonici: CC(C)OC(=O)C(CCC(=O)C=[N+]=N)NC(=O)OC(C1=CC=CC=C1)OC(=O)C(C)(C)C
• IUPAC Name: [(5S)-5-[[2,2-dimethylpropanoyloxy(phenyl)methoxy]carbonylamino]-2,6-dioxo-6-propan-2-yloxyhexylidene]-iminoazanium
• InChIKey: KCTDLEPDMHFLHZ-KKFHFHRHSA-O
• INCHI: 1S/C22H29N3O7/c1-14(2)30-18(27)17(12-11-16(26)13-24-23)25-21(29)32-19(15-9-7-6-8-10-15)31-20(28)22(3,4)5/h6-10,13-14,17,19,23H,11-12H2,1-5H3/p+1/t17-,19?/m0/s1
• PubChem CID: 126555751
• Peso molecolare: 447.48

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2079938-92-2, the molecular formula is C22H29N3O7, and the molecular weight is 447.48 g/mol. InChIKey KCTDLEPDMHFLHZ-KKFHFHRHSA-O.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.