N-(2,2-Dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide FAQ

N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide is a specialized amide-class organic reagent featuring both a dimethyl acetal moiety and a 3,4-dimethoxyphenylacetyl group, making it a versatile building block for synthetic chemistry research.

Product Name

N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide

SKU

N770721

Compound Class

Amide with dimethyl acetal functionality

Key Functional Groups

Amide (–CONH–), dimethyl acetal (–CH(OCH₃)₂), aryl dimethoxy (3,4-(OCH₃)₂)

Supplier

Aladdin Scientific

Typical Application

Synthetic intermediate in organic and medicinal chemistry research

What Is N-(2,2-Dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide?

N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide is an organic amide compound that combines a 3,4-dimethoxyphenylacetic acid-derived acyl fragment with an aminoacetaldehyde dimethyl acetal-derived amine fragment. The molecule contains three methoxy groups in total: two on the aromatic ring at the 3- and 4-positions and two as part of the acetal on the ethyl chain, along with the central amide bond.

Because it simultaneously presents a masked aldehyde (as the dimethyl acetal) and an electron-rich methoxylated aromatic ring, this compound is of particular interest as a bifunctional building block in multi-step organic synthesis. The acetal group can be selectively hydrolyzed under mild acidic conditions to reveal the corresponding aldehyde, enabling downstream condensation and cyclization reactions.

Handling, Storage and Stability

As with most acetal- and amide-containing reagents, N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide should be stored in a tightly sealed container, away from moisture and strong acids, which can cause premature hydrolysis of the acetal group. A cool, dry environment (typically 2–8 °C or room temperature depending on the lot-specific certificate of analysis) is recommended.

Researchers should consult the Safety Data Sheet (SDS) supplied with each lot before handling. Standard personal protective equipment—including nitrile gloves, safety glasses, and a laboratory coat—should be worn. Work in a well-ventilated area or fume hood when weighing or dissolving the compound.

Verify exact storage temperature, shelf life, and stability data on the certificate of analysis (CoA) provided with your specific lot, as these values may vary.

Typical Research Applications

N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide serves primarily as a synthetic intermediate in organic and medicinal chemistry. Its structural features—an acetal-protected aldehyde tethered to an amide nitrogen and an electron-rich aromatic system—make it suitable for the preparation of heterocyclic scaffolds, including isoquinolines, dihydroisoquinolines, and related nitrogen-containing ring systems that are prevalent in biologically active natural products and drug candidates.

The 3,4-dimethoxyphenyl (veratryl) motif is commonly found in compounds related to the dopaminergic system and alkaloid synthesis, further supporting the utility of this reagent in pharmacological research contexts. Always verify the suitability of this reagent for your specific application through your own experimental validation.

Ordering and Product Availability

N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide is available from Aladdin Scientific under SKU N770721. To place an order, visit the Aladdin Scientific website, search by product name or SKU, and add the desired pack size to your cart. For bulk quantities, custom pack sizes, or institutional purchasing agreements, please contact our sales team directly.

Registered account holders benefit from streamlined reordering, access to certificates of analysis, and eligibility for reward points, coupons, and promotional pricing. If you are a new customer, creating a free account takes only a few minutes and unlocks full ordering functionality.

Quality, Purity and Documentation

Aladdin Scientific provides a certificate of analysis (CoA) for each lot of N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide (SKU N770721), detailing purity, analytical methods employed, and lot-specific test results. A Safety Data Sheet (SDS) is also available for download from the product page or upon request.

If you have specific purity requirements for your research application—such as HPLC-grade purity or a defined impurity profile—please contact our technical support team prior to ordering to confirm that the available lot meets your specifications. Custom synthesis or additional analytical characterization may be available upon request for specialized research needs.

Frequently asked questions

What is the CAS number or molecular formula of N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide?

The molecular formula can be derived from the IUPAC name: the compound consists of a 3,4-dimethoxyphenylacetyl group coupled to a 2,2-dimethoxyethylamine, giving a formula of C₁₄H₂₁NO₅. The exact CAS number and confirmed molecular weight should be verified on the certificate of analysis or the product page for SKU N770721, as Aladdin Scientific lists lot-specific verified data there.

How should I dissolve N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide for use in reactions?

Common organic solvents such as dichloromethane, ethyl acetate, dimethyl sulfoxide (DMSO), and methanol are generally suitable for dissolving amide compounds of this structural class. Solubility in aqueous systems is expected to be limited due to the hydrophobic aromatic and acetal groups. Always prepare a small test dissolution before scaling up, and avoid prolonged contact with aqueous acid, which may hydrolyze the acetal functionality.

Can the acetal group in this compound be selectively hydrolyzed to reveal the aldehyde?

Yes. Dimethyl acetals are well-established protecting groups for aldehydes that can be cleanly removed under mildly acidic aqueous conditions (for example, dilute hydrochloric acid or p-toluenesulfonic acid in aqueous acetone or THF) to reveal the free aldehyde. Care should be taken to select conditions that do not simultaneously cleave the amide bond or affect other sensitive functional groups in the target molecule.

How do I obtain a Safety Data Sheet (SDS) or Certificate of Analysis (CoA) for SKU N770721?

SDS and CoA documents for SKU N770721 are available directly on the product page of the Aladdin Scientific website. Registered users can also access lot-specific CoA documents through their account portal. If you require documentation not listed online, please contact Aladdin Scientific customer service with your lot number and order reference.

Is N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide available in bulk or custom quantities?

Aladdin Scientific offers various pack sizes for research reagents, and bulk or custom quantity requests can typically be accommodated by contacting the sales team directly. Pricing and lead times for non-standard quantities are provided on a quotation basis. Institutional and recurring-order customers may also inquire about preferential pricing arrangements.

References

1. Aladdin Scientific product page for N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide, SKU N770721.
2. Greene, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, 4th ed.; Wiley-Interscience: New York, 2007. (General reference for acetal protecting group chemistry.)

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.