4-Methoxy-2,3,5-trimethylpyridine: Properties & Lab Uses

4-Methoxy-2,3,5-trimethylpyridine is a methoxy-substituted trimethylpyridine heterocycle of interest in organic synthesis, flavor and fragrance research, and the preparation of more complex pyridine-based intermediates.

Chemical Name

4-Methoxy-2,3,5-trimethylpyridine

SKU

M695687

Molecular Formula

C9H13NO

Compound Class

Substituted pyridine (methoxypyridine)

Key Functional Groups

Methoxy group (-OCH3), pyridine ring nitrogen, three methyl substituents

Supplier

Aladdin Scientific

Chemical Identity and Structure

4-Methoxy-2,3,5-trimethylpyridine is a substituted pyridine in which the pyridine ring bears methyl groups at the 2-, 3-, and 5-positions and a methoxy group at the 4-position. Its molecular formula is C₉H₁₃NO, reflecting the combination of the six-membered nitrogen-containing aromatic ring with three methyl substituents and one methoxy substituent. The presence of the electron-donating methoxy group at the 4-position and the three methyl groups significantly influences the electron density distribution on the ring, affecting reactivity in electrophilic and nucleophilic reactions. This substitution pattern distinguishes it from simpler pyridine derivatives and is relevant to its applications in synthetic and flavor chemistry.

Applications in Research and Synthesis

4-Methoxy-2,3,5-trimethylpyridine serves as a versatile building block in organic synthesis, particularly in the construction of more complex heterocyclic frameworks. Methoxypyridines are widely employed as intermediates in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals, where the methoxy group can be further transformed—for example, by demethylation to yield hydroxypyridines or by nucleophilic aromatic substitution to introduce other functional groups.

In the context of flavor and fragrance chemistry, alkyl- and methoxy-substituted pyridines are known to occur naturally in food matrices and contribute characteristic aroma notes. Research into such compounds supports quality control and sensory analysis efforts in the food science sector. Procurement teams sourcing this compound should verify purity specifications with Aladdin Scientific to ensure suitability for sensitive analytical or synthetic applications.

Handling, Storage, and Safety Considerations

As with most organic reagents containing nitrogen heterocycles, 4-Methoxy-2,3,5-trimethylpyridine should be handled in accordance with standard laboratory safety protocols. Users are advised to consult the Safety Data Sheet (SDS) provided by Aladdin Scientific before use. General precautions include working in a well-ventilated area or fume hood, wearing appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat, and avoiding contact with skin, eyes, and mucous membranes.

The compound should be stored in a tightly sealed container, away from heat, ignition sources, and incompatible materials such as strong oxidizers. Storage under cool, dry conditions helps maintain compound integrity over time. Researchers should dispose of waste materials in compliance with local regulations governing the disposal of organic chemical waste.

Ordering and Availability from Aladdin Scientific

4-Methoxy-2,3,5-trimethylpyridine is available from Aladdin Scientific under SKU M695687. Researchers and procurement professionals can request detailed product specifications, purity certificates (CoA), and SDS documents directly through Aladdin Scientific's customer service or online portal. When placing an order, it is recommended to confirm current stock availability, lead times, and packaging options to meet project timelines.

For bulk purchasing inquiries or custom packaging requirements, Aladdin Scientific's sales team can provide tailored quotations. Reward points, promotional pricing, and institutional account options may apply—contact Aladdin Scientific for up-to-date pricing and promotions relevant to your procurement needs.

Frequently asked questions

What is 4-Methoxy-2,3,5-trimethylpyridine used for in research?

4-Methoxy-2,3,5-trimethylpyridine is used as a synthetic intermediate in heterocyclic and medicinal chemistry, as a building block for the preparation of pharmaceuticals, agrochemicals, and fine chemicals, and as a reference compound in flavor and fragrance research involving alkyl-substituted pyridines.

What is the molecular formula of 4-Methoxy-2,3,5-trimethylpyridine?

The molecular formula of 4-Methoxy-2,3,5-trimethylpyridine is C9H13NO, corresponding to a substituted pyridine ring with three methyl groups (at positions 2, 3, and 5) and one methoxy group (at position 4).

How should 4-Methoxy-2,3,5-trimethylpyridine be stored?

This compound should be stored in a tightly sealed container under cool, dry conditions, away from heat sources, direct sunlight, and strong oxidizing agents. Always consult the Aladdin Scientific SDS for compound-specific storage recommendations before use.

How can I order 4-Methoxy-2,3,5-trimethylpyridine from Aladdin Scientific?

You can order 4-Methoxy-2,3,5-trimethylpyridine directly through Aladdin Scientific's website or by contacting the sales team, using SKU M695687. For bulk orders or custom packaging, reach out to Aladdin Scientific's customer service for a tailored quotation.

References

1. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley-Interscience. (General reference for nucleophilic aromatic substitution and pyridine chemistry.)
2. Clayden, J.; Greeves, N.; Warren, S. Organic Chemistry. Oxford University Press. (General reference for heterocyclic chemistry principles.)
3. Aladdin Scientific Product Page: 4-Methoxy-2,3,5-trimethylpyridine, SKU M695687.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.