KCC2 blocker 1 - 10mM in DMSO , CAS No.1228439-36-8

CAS: 1228439-36-8 Cat. No.: K656859 Formula: C₂₂H₂₅NO₅S Peso molecolare: 415.50 PubChem CID: 46866400

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

KCC2 blocker 1 is an orally active and selective K + -Cl - cotransporter KCC2 blocker with an IC 50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate

In Vitro

KCC2 blocker 1 (compound 13; 100 μM) inhibits NKCC1 with 35%. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KCC2 blocker 1 (compound 13; 1 mg/kg iv and 6 mg/kg po) has a t 1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL for male Wistar rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats Dosage: 1 mg/kg or 6 mg/kg (Pharmacokinetic Analysis) Administration: IV (1 mg/kg) and PO (6 mg/kg) Result: Had a t 1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL.

IC50& Target:IC50: 1 μM (KCC2)

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

KCC2 blocker 1 is an orally active and selective K + -Cl - cotransporter KCC2 blocker with an IC 50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Nomi e identificatori

• Isomeri SMILES: CC(=O)N1CCCC1(CC2=CC=C(C=C2)S(=O)(=O)C)C(=O)OCC3=CC=CC=C3
• PubChem CID: 46866400
• Peso molecolare: 415.50

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1228439-36-8, the molecular formula is C22H25NO5S, and the molecular weight is 415.50 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.