≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
KSI-3716 is a potent c-Myc inhibitor that blocks c-MYC/MAX binding to target gene promoters. KSI-3716 is an effective intravesical chemotherapy agent for bladder cancer
In Vitro
KSI-3716 blocks c-MYC/MAX from forming a complex with target gene promoters. KSI-3716 effectively blocks complex formation in a dose dependent manner (IC 50 =0.84 μM). c-MYC mediated transcriptional activity is inhibited by KSI-3716 at concentrations as low as 1 μM. The expression of c-MYC target genes, such as cyclin D2, CDK4 and hTERT, is markedly decreased. KSI-3716 exerts cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Intravesical instillation of KSI-3716 at a dose of 5 mg/kg significantly suppresses tumor growth with minimal systemic toxicity . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:c-Myc
Specifications
Specifiche e purezza
≥99%
Meccanismi biochimici e fisiologici
KSI-3716 is a potent c-Myc inhibitor that blocks c-MYC/MAX binding to target gene promoters. KSI-3716 is an effective intravesical chemotherapy agent for bladder cancer.
Condizioni di conservazione di stoccaggio
Store at -20°C
Spedito in
Ice chest + Ice pads
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
This compound belongs to the class of organic compounds known as aminoquinolines and derivatives. These are organic compounds containing an amino group attached to a quinoline ring system.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Proprietà chimiche e fisiche
Solubilità
DMSO : 5 mg/mL (11.73 mM; Need ultrasonic)
Calcolatori di soluzioni
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
Recensioni
Recensioni dei clienti
Application Protocols
Item-specific facts
No tested applications or recommended dilutions are provided for KSI-3716.
General protocol guidance (screening context)
Stock preparation: Dissolve in anhydrous DMSO to 10–50 mM. Vortex and, if needed, sonicate briefly. Filter (0.22 µm PTFE) for particulate removal.
Plate handling: Aliquot into low-binding plates or tubes to minimize adsorption; seal to limit evaporation. Avoid more than 3 freeze–thaw cycles by preparing single-use aliquots.
Dosing: Normalize vehicle to a constant final DMSO fraction (typically 0.2–1.0% v/v). Include vehicle and positive/negative controls on every plate; use interleaved titration series for potency estimation.
Interference checks: Assess fluorescence/absorbance overlap with assay readout; evaluate aggregation with a low-concentration non-ionic detergent and by DLS if possible.
Documentation: Record lot number, stock concentration, preparation date, and storage conditions; verify by LC-MS periodically for long studies.
Biological Roles
Item-specific facts
No biological function, pathway association, or target information is provided for KSI-3716.
General note for screening molecules
As a library compound, any biological role is undetermined until evaluated experimentally. Such molecules are typically profiled across panels (enzymes, receptors, ion channels) or phenotypic assays to uncover potential activities.
Recommended characterization (research use only)
Primary potency screening followed by orthogonal confirmation to rule out assay artifacts.
Basic ADME-style in vitro profiling: aqueous solubility, chemical stability (buffer, pH 2–9), microsomal stability (if relevant), and plasma protein binding to contextualize observed activity.
PAINS and REOS filters: Apply computational flags cautiously and confirm experimentally to avoid discarding valid chemotypes.
Caution
Do not infer therapeutic relevance or physiological roles without robust, peer-reviewed evidence. This product is supplied strictly for laboratory research use.
Buffer Applications
Applicability note
KSI-3716 is a small-molecule library compound, not a buffering agent. It does not constitute a pH buffer system.
Practical guidance (when dosing into buffers)
Prepare concentrated DMSO stocks and dilute into assay buffers (e.g., PBS, HEPES, Tris) keeping final organic content ≤0.5–1.0% v/v or as assay-tolerated.
Verify absence of precipitation upon dilution; if needed, include a small percentage of co-solvent (e.g., 2–5% DMSO) or a non-ionic surfactant (0.01% Tween-20) after confirming assay compatibility.
For pH-sensitive studies, evaluate apparent solubility at multiple pH values (2, 7.4, 9) to ensure consistent dosing and to detect ionization-dependent behavior.
Green Alternatives
Context
The primary environmental footprint for screening compounds typically arises from solvent use in dissolution, assay preparation, and analytical support. No structure-specific greener synthesis guidance can be provided without identity details.
Greener dissolution and handling options (general)
Prefer aqueous buffers with minimal cosolvent when compatible with solubility and assay requirements.
If organic cosolvent is necessary, consider reducing DMSO percentage and evaluating biofriendly alternatives (e.g., ethanol) within assay tolerance.
For analytic sample prep, minimize solvent volumes and choose lower-toxicity options (ethanol, isopropanol, ethyl acetate) where performance allows.
Illustrative comparison (general attributes)
DMSO: Excellent solubilizer; low volatility; relatively benign but persistent; can affect cell membranes at >1%.
Ethanol: Renewable origin possible; higher volatility; limited solubility for very lipophilic compounds; often well tolerated biologically at ≤0.5%.
PEG-400 (co-solvent): Low volatility; improves solubility of hydrophobes; viscosity can complicate liquid handling; consider for in vivo formulation research (note: product is for research use only, not clinical).
Operational greening
Use miniaturized assay formats (384/1536-well) to cut solvent and compound usage.
Implement solvent recycling for chromatography where feasible and select water-rich mobile phases when LC resolution allows.
Pharmaceutical Uses
Not applicable to this catalog item
No excipient role, pharmacopeial status, or formulation monograph is provided for KSI-3716. It is supplied for research use only and not for human or veterinary use.
Research formulation context (general)
For in vitro assays, DMSO stock solutions are standard. For exploratory in vivo research models (where institutionally permitted), co-solvent systems (e.g., PEG-400/saline, ethanol/cremophor/saline) are sometimes used to enhance solubility; assess local regulations and institutional approvals. Note: Aladdin Scientific supplies this product strictly for laboratory research use; no clinical application is implied.
Quality considerations
If formulation behavior (e.g., precipitation, adsorption to plastics) impacts experimental outcomes, consider pre-screening alternative vehicles and container materials (glass vs polypropylene) and confirm compound recovery by LC-MS.
Physical Properties
Item-specific facts (from Product Data)
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Not provided for this item (consult CoA/SDS)
Melting point / Boiling point
Density
Solubility (water/organic)
pKa, logP/logD
Refractive index, UV/Vis characteristics
Practical notes for unknown small molecules (general literature guidance)
Solubility screening workflow: test DMSO (50–100 mg/mL target), then common organics (MeOH, EtOH, acetonitrile, DMF), followed by cosolvent–buffer mixtures (e.g., 5–20% DMSO or MeOH in PBS) as needed for assays.
If ionizable groups are suspected, construct a small pH–solubility profile (buffered solutions at pH 2, 6–7, 9–10) to estimate ionization behavior.
Hygroscopicity and polymorphism can impact handling and assay reproducibility; confirm mass by Karl Fischer (for hydrates) and verify form by DSC/XRPD when critical.
Light and air sensitivity are unknown; until specified, minimize exposure to ambient light and humidity during weighing and solution prep.
Reminder
Do not treat the above as specifications. Use lot-specific CoA for numeric values and SDS for hazard-linked physical data.
Quality and Grades
Item-specific facts (from Product Data)
Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.
Interpretation and expectations
As a “small-molecule library” entry, KSI-3716 is typically supplied at research-grade purity appropriate for screening and exploratory studies. Exact assay purity (e.g., HPLC area%) and identity confirmation (NMR/MS) must be verified on the lot-specific CoA.
If UV-sensitive impurities are a concern (e.g., for photometric assays), request low-UV chromatograms or perform in-house HPLC-UV/ELSD.
Trace water/peroxides/metals: Not specified for this item; refer to CoA/Spec Sheet. For metal-sensitive biology or catalysis, independently test (e.g., ICP-MS) as needed.
Practical recommendations
For HTS and SAR, aim to use lots with ≥95% HPLC purity when possible; confirm salt form/solvate state to ensure reproducibility of molar dosing.
If the compound has multiple tautomers or stereocenters (unknown here), verify enantiomeric/diastereomeric ratio prior to mechanistic biology.
Record solution stability upon storage (freeze–thaw cycles in DMSO, light exposure) with periodic re-check by LC-MS to ensure assay integrity.
Reaction and Applications
Scope note
KSI-3716 is cataloged as a small-molecule library member for research use. No manufacturer reaction-use claims or specific application notes were provided.
Research applications (general for screening compounds)
Chemical biology: Use as a test article in phenotypic or target-based assays to probe pathway responses and generate preliminary SAR.
Assay development: Evaluate compound performance across assay modalities (biochemical enzyme assays, cell-based readouts, binding biophysics such as SPR/DSF/ITC) to characterize potency and basic ADME-like attributes (solubility, stability in buffer, nonspecific binding).
Profiling: Run counter-screens for assay interference (e.g., redox cycling, fluorescence quenching, aggregation via detergent-sensitive assays) before concluding on mechanism.
Practical considerations
Prepare fresh DMSO stocks and minimize freeze–thaw cycles. Include vehicle controls matching final DMSO content.
Check for colloidal aggregation using detergent addition (0.01% Tween-20 or 0.01% Triton X-100) and dynamic light scattering where available.
If the compound is colored or UV-active, account for inner filter effects in fluorescence assays by appropriate dilution and instrument settings.
Limitations
Without structural information, no specific reactivity or named-reaction utility can be asserted. For synthesis-oriented use, consult the CoA/SDS or PubChem entry for functional group guidance.
Reaction Conditions
Not applicable without structural details
No reaction condition guidance can be offered for KSI-3716 because functional groups, stability windows, and reactivity are unknown.
General considerations (if structure becomes available)
Map solvent compatibility and temperature limits via small-scale stress tests (e.g., 40–80°C in common solvents; pH 2–10 buffers) with LC-MS monitoring to define a safe operating window.
For chromatographic purification, start with reverse-phase LC screening (water/acetonitrile with 0.1% formic acid or ammonium bicarbonate) to establish retention and stability, then translate to flash conditions if needed.
Safety and Handling
Item-specific facts (from Product Data)
GHS Classification / Pictograms / Signal Word / H-Statements: Not specified for this item; refer to the SDS.
Storage: Store at −20°C.
Shipped in: Ice chest + ice pads.
General safety guidance (defer to SDS as authoritative)
PPE: lab coat, safety glasses, and suitable chemically resistant gloves (e.g., nitrile). Handle in a fume hood to avoid inhalation of dust or vapors.
Unknown hazard profile: In absence of definitive GHS data, treat as potentially harmful if swallowed, inhaled, or in contact with skin and eyes. Avoid aerosol generation and accidental ingestion.
Incompatibilities: Without structural data, avoid strong oxidizers/reducers, strong acids/bases, and reactive acylating/alkylating agents until compatibility is known.
First aid (general): Inhalation—move to fresh air; Skin—wash with soap/water; Eyes—rinse with water for 15 minutes; Ingestion—rinse mouth. Seek medical attention in all cases and provide the SDS.
Spill response: Avoid dust, collect with inert absorbent, and dispose in accordance with institutional and local regulations.
Thermal/photochemical sensitivity: Unknown; protect from heat and direct light as prudent practice.
Waste disposal
Dispose of solutions/solids as organic laboratory waste unless SDS indicates otherwise. Segregate halogenated from non-halogenated solvents where applicable.
Solvent Selection
Applicability note
Structural details are not available; solvent guidance below is general best practice for unknown small molecules used in screening.
General strategy
Primary stock solvent: DMSO is preferred for broad solubilization and biological assay compatibility. Prepare concentrated stocks (e.g., 10–50 mM) and dilute into assay buffers keeping final DMSO at ≤0.5–1.0% v/v unless assay-tolerant.
Secondary solvents: If DMSO is unsuitable, evaluate DMF, acetonitrile, methanol, or ethanol. For aqueous work, use cosolvent systems (5–20% organic in buffer) or solubilizers (e.g., 0.01–0.1% non-ionic surfactant).
Aqueous enhancement: Consider pH adjustment when ionizable groups are suspected; cyclodextrins (HP-β-CD) can improve solubility of hydrophobes.
Comparison (general)
DMSO vs MeOH/Ethanol: DMSO offers higher solubilization and lower volatility; alcohols may be preferable for UV transparency or biological tolerance constraints.
Acetonitrile: Good for LC-MS sample prep; higher volatility aids drying but may have poorer solubility for very lipophilic compounds.
Practical tips
Filter 0.22 µm before bioassays to remove particulates. Verify absence of precipitation after dilution by visual check and LC-UV scatter.
Document solvent lot and water content for sensitive assays. Use anhydrous grades for moisture-sensitive compounds pending confirmation.
Storage and Reconstitution
Item-specific facts (from Product Data)
Storage Conditions: Store at −20°C.
Shipping: Ice chest + ice pads.
General reconstitution guidance (research use only)
Solid handling: Equilibrate vial to room temperature in a desiccator before opening to prevent moisture condensation. If hygroscopicity is unknown, minimize exposure to ambient air.
Stock solutions: Prepare in anhydrous DMSO at 10–50 mM depending on anticipated solubility. Mix thoroughly (vortex/brief sonication) until fully dissolved. If insoluble, consider DMF, acetonitrile, or alcohols, then dilute into assay buffer.
Aliquoting: Dispense single-use aliquots (e.g., 10–50 µL) into low-bind microtubes or 96/384-well source plates. Store aliquots at −20°C or −80°C for long-term stability.
Freeze–thaw: Avoid repeated cycles; thaw on ice and return unused portions to storage promptly. Monitor for precipitation upon thawing and redissolve if necessary.
Light/moisture: Until data indicate otherwise, protect from light and humidity.
Stability notes
Numeric stability data and solution shelf-life are not specified for this item; refer to CoA/Spec Sheet and perform periodic LC-MS checks for extended studies.
Structure and Identity
Item-specific facts (from Product Data)
Product Name: KSI-3716 (SKU: K648815)
CAS: 1151813-61-4
PubChem CID: 44565901
InChIKey: 367592 (as provided)
SMILES: Not specified for this item; refer to CoA/Spec Sheet.
Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
Interpretive notes
KSI-3716 is listed under “小分子和化合物库” (small-molecule compound library), indicating a screening/chemical probe-type reagent for research use.
Because SMILES, formula, and structure were not provided, a definitive 2D/3D structural description, functional groups, ring systems, and stereochemistry cannot be stated here. Consult the product CoA/SDS or PubChem record (CID 44565901) for exact structural details.
General guidance
For cataloged screening molecules, identity is typically supported by NMR and MS on the CoA. Where stereochemistry exists, it should be verified against the lot-specific documentation.
If working blind to structure, treat the compound as potentially hydrophobic with limited aqueous solubility until confirmed otherwise; begin with DMSO stock solutions and characterize solubility experimentally.
Synthetic Utility
Scope note
No structural or functional group information is available for KSI-3716; therefore, specific synthetic transformations, named-reaction participation, or building-block roles cannot be described.
General guidance
If using KSI-3716 as a reference or comparator compound in SAR programs, ensure lot identity/purity by NMR and LC-MS before derivatization attempts.
For unknown functionalities, start with orthogonal reactivity screens (e.g., stability toward acids/bases, nucleophiles/electrophiles, oxidants/reductants) to infer compatible conditions prior to synthesis.
If the compound serves as a scaffold for analog generation, obtain or determine its core structure and substituent map (via spectra or literature/PubChem), then plan diversification using chemoselective strategies.
Caveat
Do not assume availability of protective group strategies or late-stage diversification routes without confirmed structural data. Consult the CoA/SDS or primary database entries for functional group annotations before planning synthesis.
Target Specificity
Item-specific facts
No target, pathway, or selectivity information is provided for KSI-3716.
Guidance for users
Treat as an uncharacterized small molecule until activity is established. If screening reveals apparent target engagement, perform orthogonal confirmation (biophysics, counterscreens) and selectivity profiling against related targets to determine specificity.
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