Ladarixin sodium - 10mM in DMSO , CAS No.865625-56-5

CAS: 865625-56-5 Cat. No.: L656609 Formula: C₁₁H₁₁F₃NNaO₆S₂ Peso molecolare: 397.32 Numero EC: 691-863-8 PubChem CID: 23709380

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Ladarixin sodium (DF 2156A) is an orally active, allosteric non-competitive and dual CXCR1 and CXCR2 antagonist. Ladarixin sodium can be used for the research of COPD and asthma

In Vitro

Ladarixin inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 (IC 50 at 0.7 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ladarixin (10 mg/kg; p.o. once a day) reduces allergic airway inflammation in a model of single OVA exposure. Ladarixin reduces allergic airway inflammation, remodeling, and bronchial hyperreactivity in a model of chronic OVA exposure . Ladarixin (10 mg/kg; p.o. once a day for 8 days) reduces pulmonary inflammation and fibrosis induced by bleomycin in mice . Ladarixin (10 mg/kg; p.o. once a day for 3 days) protects mice from cigarette smoke-induced exacerbation of influenza-A infection . Ladarixin is also effective in decreasing CXCL8-induced polymorphonuclear leukocyte infiltration in several animal models without a significant dose-related reduction in systemic neutrophil counts. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice (cigarette smoke-induced exacerbation of Influenza-A infection model) Dosage: 10 mg/kg Administration: P.o. once a day at days 2, 3 and 4 post-infection Result: Significantly attenuated the exacerbation in lethality and respiratory changes noted in CSFlu group.

IC50& Target:CXCR1 CXCR2

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Ladarixin sodium (DF 2156A) is an orally active, allosteric non-competitive and dual CXCR1 and CXCR2 antagonist. Ladarixin sodium can be used for the research of COPD and asthma.

Condizioni di conservazione di stoccaggio

Desiccated,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

ANTAGONIST

Nomi e identificatori

Isomeri SMILES

C[C@H](C1=CC=C(C=C1)OS(=O)(=O)C(F)(F)F)C(=O)[N-]S(=O)(=O)C.[Na+]

CAS alternativo

865625-56-5

PubChem CID

23709380

Termini MeSH

2'-((4'-trifluoromethanesulfonyloxy)phenyl)-N-methanesulfonylpropionamide;DF 2156A;DF 2156Y;DF-2156A;DF-2156Y;DF2156A;DF2156Y;ladarixin

Peso molecolare

397.32

Domande frequenti

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 865625-56-5, the molecular formula is C11H11F3NNaO6S2, and the molecular weight is 397.32 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.