LDHA-IN-3 - ≥99% , CAS No.227010-33-5

CAS: 227010-33-5 Cat. No.: L651150 Molecular Weight: 301.17

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase ( LDHA ) inhibitor ( IC 50 =145.2 nM). LDHA-IN-3 can be used for the research of cancer

In Vitro

PSTMB (0~500 μM; 48 hours; MCF-7 cells) shows cytotoxic effect. PSTMB (0.01~1 μM) shows dose-dependent inhibition of LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage. PSTMB can bind to LDHA protein efficiently. PSTMB induces the intrinsic pathway-mediated apoptosis of cancer cells via production of mitochondrial ROS. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cells Concentration: 0~500 μM Incubation Time: 48 hours Result: Showed cytotoxic effect.

Form:Solid

IC50& Target:IC50: 145.2 nM (LDHA)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase ( LDHA ) inhibitor ( IC 50 =145.2 nM). LDHA-IN-3 can be used for the research of cancer.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 301.17

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (332.04 mM; Need ultrasonic)