Levosimendan - Moligand™,10mM in DMSO , Troponin, cardiac muscle positive modulator, CAS No.141505-33-1, Troponin, cardiac muscle positive modulator

CAS: 141505-33-1 Cat. No.: L407801 Formula: C₁₄H₁₂N₆O Peso molecolare: 280.28 Numero EC: 663-528-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(R)-2-(2-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)hydrazono)malononitrile

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Levosimendan is acalcium sensitizeracting through calcium-dependent binding tocardiac troponin C (cTnC), provides treatment for heart failure.
In vitro

Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC). Levosimendan at 3 μM decreases the value of Ca50 from 2.73μM to 1.19 μM. levosimendan exhibits its calcium sensitizing effect through calcium-dependent binding to the N-terminal domain of cTnC. Levosimendan significantly hyperpolarizes resting potential of rat mesenteric arterial myocytes with an EC50 of 2.9 μM and maximal effect (19.5 mV) at 10 μM, probably through activation of a glibenclamide-sensitive K⁺ channel. Levosimendan has inotropic and lusitropic actions in failing human myocardium, with average maximum increase in twitch tension of 47% at a levosimendan concentration of 0.8 μM. Levosimendan causes rapid dose-dependent improvement in hemodynamic function in patients with decompensated heart failure.

In vivo

Levosimendan at low concentrations (0.03 to 0.1 μM) acts preferably as a Ca2+ sensitizer, whereas at higher concentrations (0.1 to 0.3 μmol/L) its action as a phosphodiesterase inhibitor contributes to the positive inotropic effect.
Cell Data

cell lines：A2780, A2780/cp70, 2780AD, HCT116, HT29, WIL, CALU-3, MCF7, PC3 and HS852

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

(R)-2-(2-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)hydrazono)malononitrile

Specifiche e purezza

Moligand™,10mM in DMSO

Meccanismi biochimici e fisiologici

Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

Troponin, cardiac muscle positive modulator

Proprietà del prodotto

• ALogP: 2.3

Nomi e identificatori

• Isomeri SMILES: C[C@@H]1CC(=O)NN=C1C2=CC=C(C=C2)NN=C(C#N)C#N
• WGK Germania: 3
• RTECS: TY1570210
• Peso molecolare: 280.28
• Reaxy-Rn: 6959884
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6959884&ln=

Proprietà chimiche e fisiche

• Rotazione specifica [α]: -627° (C=0.5,THF)
• Punto di fusione (°C): 210-214°C