Modulatori dei checkpoint immunitari

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  1. Avelumab (anti-PD-L1), OTHER of Programmed cell death 1 ligand 1 other
    CAS: 1537032-82-8 PubChem CID: 168266339
    Liquido Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: A412006
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    Associated targets
    CD274
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Specie reattive
    Coniglio, consiglio, Cynomolgus monkey, Mouse, Tuttavia, Umano
    Isotipo
    Human IgG1
    Specie ospite
    Umano
    Coniugazione
    Unconjugated
    Nome IUPAC
    4-O-[2-(tert-butylsulfonylamino)-2-phenylethyl] 1-O-methyl but-2-enedioate;4-O-[2-(cyclohexylmethylsulfonylamino)-2-phenylethyl] 1-O-methyl but-2-enedshow more
    SMILES
    CCS(=O)(=O)NC(COC(=O)C=CC(=O)OC)C1=CC=CC=C1.CC(C)CS(=O)(=O)NC(COC(=O)C=CC(=O)OC)C1=CC=CC=C1.CC(C)S(=O)(=O)NC(COC(=O)C=CC(=O)OC)C1=CC=CC=C1.CC(C)(C)CS(show more
    InChIKey
    YRKYEQYAGDIKGE-UHFFFAOYSA-N
    InChI
    1S/C20H27NO6S.C19H25NO6S.C18H25NO6S.2C17H23NO6S.C16H21NO6S.C15H19NO6S.C14H17NO6S/c1-26-19(22)12-13-20(23)27-14-18(17-10-6-3-7-11-17)21-28(24,25)15-16-show more
    Sinonimi
    Recombinant Avelumab Antibody | Avelumab | Anti-Human PD-L1, Human Antibody | Anti-PD-L1 | MSB0010718C | Bavencio | B...
  2. Cemiplimab (anti-PD-1), Antibody of programmed cell death 1 (CD279)
    CAS: 1801342-60-8
    Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: C412010
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    Associated targets
    PDCD1
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Specie reattive
    Umano
    Isotipo
    Human IgG4
    Specie ospite
    Umano
    Coniugazione
    Unconjugated
    Sinonimi
    hPD-1 | Protein PD-1
  3. Durvalumab (anti-PD-L1), INHIBITOR of Programmed cell death 1 ligand 1 inhibitor
    CAS: 1428935-60-7
    Liquido Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: D412005
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    Associated targets
    CD274
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<0.01EU/μg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Specie reattive
    Cynomolgus monkey, Mouse, Umano
    Isotipo
    Human IgG1
    Specie ospite
    Umano
    Coniugazione
    Unconjugated
    Sinonimi
    Durvalumab (anti-PD-L1) | MEDI4736 | Durvalumab | MEDI 4736 | Anti-B7-H1 / PD-L1 / CD274 Reference Antibody (durvalum...
  4. Ipilimumab (anti-CTLA-4), Antibody of cytotoxic T-lymphocyte-associated protein 4 (CD152)
    CAS: 477202-00-9 Numero EC: 274-324-8, 232-352-8, 639-663-1 PubChem CID: 167312542
    Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: I411993
    Visualizza prodotto
    Prezzi e dimensioni del pacchetto
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    Associated targets
    CTLA4
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<0.01EU/μg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Specie reattive
    Cynomolgus monkey, Mouse, Umano
    Isotipo
    Human IgG1
    Specie ospite
    Umano
    Coniugazione
    Unconjugated
    Nome IUPAC
    3-butyl-4-hydroxy-5-methyl-5-(2-methylbuta-1,3-dienyl)thiophen-2-one;4-ethyl-2-methyl-2-(2-methylbuta-1,3-dienyl)-5-methylidenethiophen-3-ol;4-hydroxyshow more
    SMILES
    CCCCC1=C(C(SC1=O)(C)C=C(C)C=C)O.CCCC1=C(C(SC1=O)(C)C=C(C)C=C)O.CCC1=C(C(SC1=C)(C)C=C(C)C=C)O.CC1=CC=C(C=C1)CCCCC2=C(C(SC2=O)(C)C=C(C)C=C)O.CC1=CC=C(C=show more
    InChIKey
    QZWDCJBBGBXHMW-UHFFFAOYSA-N
    InChI
    1S/4C21H26O2S.2C19H22O2S.C14H20O2S.C13H18O2S.C13H18OS/c4*1-5-15(2)14-21(4)19(22)18(20(23)24-21)9-7-6-8-17-12-10-16(3)11-13-17;2*1-5-13(2)12-19(4)17(20show more
    Sinonimi
    MDX-010 | BMS-734016 | Yervoy | Ipilimumab | Ipilimumab (anti-CTLA-4) | Recombinant Ipilimumab Antibody | Ipilimumab ...
  5. Pembrolizumab (anti-PD-1), Antibody of programmed cell death 1 (CD279)
    CAS: 1374853-91-4 Numero EC: 807-012-2 PubChem CID: 168009853
    Liquido Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: P411997
    Visualizza prodotto
    Prezzi e dimensioni del pacchetto
    Identificatori tecnici
    Associated targets
    PDCD1
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Specie reattive
    Cynomolgus monkey, Umano
    Isotipo
    Human IgG4SP
    Specie ospite
    Umano
    Coniugazione
    Unconjugated
    Nome IUPAC
    1-butyl-4-propylpiperazine;ethane;1-[hex-5-enyl(2-methyltetradecyl)amino]tetradecan-2-ol;3-[2-methylhexadeca-8,10-dienyl(2-methylhexadeca-9,11-dienyl)show more
    SMILES
    CC.CCCCCCCCCCCCC(C)CN(CCCCC=C)CC(CCCCCCCCCCCC)O.CCCCCC=CC=CCCCCCC(C)CN(CCCS)CC(C)CCCCCCC=CC=CCCCC.CCCCN1CCN(CC1)CCC
    InChIKey
    AMOIBCKFWIUEKF-UHFFFAOYSA-N
    InChI
    1S/C37H69NS.C35H71NO.C11H24N2.C2H6/c1-5-7-9-11-13-15-17-19-21-23-25-27-30-36(3)34-38(32-29-33-39)35-37(4)31-28-26-24-22-20-18-16-14-12-10-8-6-2;1-5-8-show more
    Sinonimi
    1374853-91-4 | 1-butyl-4-propylpiperazine;ethane;1-[hex-5-enyl(2-methyltetradecyl)amino]tetradecan-2-ol;3-[[(8E,10E)-...
  6. belatacept, Fusion protein of CD80;Fusion protein of CD86
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Fabbricato su ordinazione negli USA · 2–4 settimane Oggetto #: rp173527
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    Sinonimi
    BMS-224818 | LEA29Y | Nulojix
  7. programmed cell death 1 ligand 1, programmed cell death 1 (CD279)
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Fabbricato su ordinazione negli USA · 2–4 settimane Oggetto #: rp174805
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    Sinonimi
    B7 homolog 1 | B7-H1 | PD-L1 | PDL1 | programmed death ligand 1
  8. CCT244747
    CAS: 1404095-34-6 Formula: C20H24N8O2 Peso molecolare: 408.46
    Liquido Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ◐ .Su ordinazione · 8–12 settimane Oggetto #: C655639
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  9. CCT241533 hydrochloride
    CAS: 1431697-96-9 PubChem CID: 136218645 Formula: C23H28ClFN4O4 Peso molecolare: 478.94
    ◐ .Su ordinazione · 8–12 settimane Oggetto #: C647075
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    Nome IUPAC
    4-fluoro-2-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxyquinazolin-2-yl]phenol;hydrochloride
    SMILES
    CC(C)(C1CNCC1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)C4=C(C=CC(=C4)F)O)O.Cl
    InChIKey
    LAKJUTZIXHTMPC-SSPJITILSA-N
    InChI
    1S/C23H27FN4O4.ClH/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29;/h5-9,15,17,25,29-30H,10-11H2,1show more
    Sinonimi
    A908287 | 1431697-96-9 | CCT241533 (hydrochloride) | HY-14715B | F84890 | AKOS030526529 | 4-Fluoro-2-(4-(((3S,4R)-4-(...
  10. ANI-7
    CAS: 931417-26-4 PubChem CID: 11565176 Formula: C13H8Cl2N2 Peso molecolare: 263.12
    ◐ .Su ordinazione · 8–12 settimane Oggetto #: A648810
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    Nome IUPAC
    (Z)-2-(3,4-dichlorophenyl)-3-(1H-pyrrol-2-yl)prop-2-enenitrile
    SMILES
    C1=CNC(=C1)C=C(C#N)C2=CC(=C(C=C2)Cl)Cl
    InChIKey
    IJJHHDLGGYDXGD-UXBLZVDNSA-N
    InChI
    1S/C13H8Cl2N2/c14-12-4-3-9(7-13(12)15)10(8-16)6-11-2-1-5-17-11/h1-7,17H/b10-6+
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Domande frequenti

What should I consider when selecting an Immune checkpoint modulators product?
Define the transformation first, then narrow the Immune checkpoint modulators listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
What does Immune checkpoint modulators cover?
Immune checkpoint modulators is a top-level listing in our catalogue. Use the filters and search on the listing page to narrow by the attributes that matter for your work, or browse the neighbouring categories from the main navigation.
Which quality data should I check before ordering Immune checkpoint modulators?
Review the lot-specific Certificate of Analysis for the Immune checkpoint modulators product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search Immune checkpoint modulators by structure or CAS number?
Yes. Within Immune checkpoint modulators you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].

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