Linrodostat (BMS-986205) - Moligand™, 10mM in DMSO , Inhibitor of indoleamine 2;3-dioxygenase 1, CAS No.1923833-60-6, Inhibitor of indoleamine 2;3-dioxygenase 1

CAS: 1923833-60-6 Cat. No.: L408060 Formula: C₂₄H₂₄ClFN₂O Peso molecolare: 410.91

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

ONO-7701 | Cyclohexaneacetamide​, N-​(4-​chlorophenyl)​-​4-​(6-​fluoro-​4-​quinolinyl)​-​α-​methyl-​, cis-​(αR)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Linrodostat (BMS-986205) Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptopha
In vitro

BMS-986205 exhibits potent inhibition of kynurenine (kyn) production in IDO1-HEK293 cells (IC50 = 1.1 nM) but not in TDO-HEK293 cells. It is an irreversible suicide inhibitor.

In vivo

Cell Data

cell lines：KMS11 and KMS18

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

ONO-7701 | Cyclohexaneacetamide​, N-​(4-​chlorophenyl)​-​4-​(6-​fluoro-​4-​quinolinyl)​-​α-​methyl-​, cis-​(αR)​-

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

Inhibitor of indoleamine 2;3-dioxygenase 1

Nomi e identificatori

• Isomeri SMILES: C[C@H](C1CCC(CC1)C2=C3C=C(C=CC3=NC=C2)F)C(=O)NC4=CC=C(C=C4)Cl
• CAS alternativo: 1923833-60-6
• Termini MeSH: (2R)-N-(4-Chlorophenyl)-2-(cis-4-(6-fluoro-4-quinolinyl)cyclohexyl)propanamide;BMS-986205;Cyclohexaneacetamide, N-(4-chlorophenyl)-4-(6-fluoro-4-quinolinyl)-\u03b1-methyl-, cis-;linrodostat
• Peso molecolare: 410.91
• Reaxy-Rn: 39662458
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=39662458&ln=

Obiettivi associati (umani)

IDO1 Tchem Indoleamine 2,3-dioxygenase 1 (0 Activities)

Discover Target: IDO1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1923833-60-6, the molecular formula is C24H24ClFN2O, and the molecular weight is 410.91 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.