Loreclezole - Moligand™, ≥98% , CAS No.117857-45-1

CAS: 117857-45-1 Cat. No.: L337898 Formula: C10H6Cl3N3 Peso molecolare: 274.53
Disponibile su ordine
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
HY-105272 | BS-14505 | Loreclezole [USAN:INN:BAN] | 6DJ32STZ5W | DTXSID6048252 | LORECLEZOLE [USAN] | R 72063 | Loreclezol [INN-Spanish] | Loreclezole | GTPL5466 | LORECLEZOLE [INN] | (Z)-1-(.beta.,2,4-Trichlorostyryl)-1H-1,2,4-triazole
Storage
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
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Size
Germania (EU)
USA*
Price
Qty
1mg
L337898-1mg
Su ordinazione · 8–12 settimane

8,59€

12,93€
Salva 4,34 € (33.56%)
5mg
L337898-5mg
Su ordinazione · 8–12 settimane

28,55€

43,30€
Salva 14,75 € (34.07%)
10mg
L337898-10mg
Su ordinazione · 8–12 settimane

51,98€

78,01€
Salva 26,03 € (33.37%)
25mg
L337898-25mg
Su ordinazione · 8–12 settimane

112,72€

169,12€
Salva 56,40 € (33.35%)
50mg
L337898-50mg
Su ordinazione · 8–12 settimane

202,96€

304,49€
Salva 101,53 € (33.34%)
100mg
L337898-100mg
Su ordinazione · 8–12 settimane

364,36€

546,59€
Salva 182,23 € (33.34%)
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Panoramica

Loreclezole hydrochloride is a subtype-selective GABA|A|receptor agonist. Positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABA|A|receptor sensitization. Inhibits homomeric ρ1 GABA|C|receptors.

Specifications

Sinonimi
HY-105272 | BS-14505 | Loreclezole [USAN:INN:BAN] | 6DJ32STZ5W | DTXSID6048252 | LORECLEZOLE [USAN] | R 72063 | Loreclezol [INN-Spanish] | Loreclezole | GTPL5466 | LORECLEZOLE [INN] | (Z)-1-(.beta.,2,4-Trichlorostyryl)-1H-1,2,4-triazole
Specifiche e purezza
Moligand™, ≥98%
Condizioni di conservazione di stoccaggio
Store at -20°C,Desiccated
Spedito in
Ice chest + Ice pads
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Grado
Moligand™
Tipo di azione
AGONIST
Purezza
≥98%
Nomi e identificatori
Sorrisi canoniciC1=CC(=C(C=C1Cl)Cl)C(=CN2C=NC=N2)Cl
IUPAC Name1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1,2,4-triazole
InChIKeyXGLHZTBDUXXHOM-WMZJFQQLSA-N
INCHI1S/C10H6Cl3N3/c11-7-1-2-8(9(12)3-7)10(13)4-16-6-14-5-15-16/h1-6H/b10-4-
Isomeri SMILES C1=CC(=C(C=C1Cl)Cl)/C(=C/N2C=NC=N2)/Cl
RTECS XZ4382000
Peso molecolare 274.53

Documentazione

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClasseBenzene and substituted derivatives
SubclassHalobenzenes
Intermediate Tree Nodes Chlorobenzenes
Direct ParentDichlorobenzenes
Alternative Parents Styrenes  Aryl chlorides  Triazoles  Heteroaromatic compounds  Vinyl chlorides  Chloroalkenes  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents 1,3-dichlorobenzene - Styrene - Aryl chloride - Aryl halide - Azole - Heteroaromatic compound - 1,2,4-triazole - Azacycle - Chloroalkene - Haloalkene - Vinyl chloride - Vinyl halide - Organoheterocyclic compound - Organochloride - Organonitrogen compound - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organohalogen compound - Aromatic heteromonocyclic compound
DescrizioneThis compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it.
External Descriptors Not available
Struttura 3D
Modello di struttura chimica interattiva





Obiettivi associati (umani)
CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA-A receptor; alpha-1/beta-3/gamma-2 (1565 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Obiettivi associati (non umani)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrg2 Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2 (184 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Meccanismi d'azione
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Proprietà chimiche e fisiche
SolubilitàSoluble in ethanol (5 mM with gentle warming), and DMSO (5 mM with gentle warming).
Indice di rifrazionen20D1.65 (Predicted)
Punto di ebollizione (°C)442.7° C at 760 mmHg (Predicted)
Peso molecolare274.500 g/mol
XLogP33.800
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass272.963 Da
Monoisotopic Mass272.963 Da
Topological Polar Surface Area30.700 Ų
Heavy Atom Count16
Formal Charge0
Complexity272.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds1
Covalently-Bonded Unit Count1
Calcolatori di soluzioni
Recensioni

Recensioni dei clienti

Domande frequenti

What is the purity of this product?
This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 117857-45-1, the molecular formula is C10H6Cl3N3, and the molecular weight is 274.53 g/mol. InChIKey XGLHZTBDUXXHOM-WMZJFQQLSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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