Lumefantrine - Moligand™, ≥98%(HPLC) , Ferriprotoporphyrin IX inhibitor, CAS No.82186-77-4, Ferriprotoporphyrin IX inhibitor

CAS: 82186-77-4 Cat. No.: L136783 Molecular Weight: 528.94 EC Number: 617-303-4

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

2-Dibutylamino-1-[2,7-dichloro-9-(4-chloro-benzylidene)-9H-fluoren-4-yl]-ethanol | 9H-Fluorene-4-methanol, 2,7-dichloro-9-((4-chlorophenyl)methylene)-alpha-((dibutylamino)methyl)-, (9Z)-(-)- | LUMEFANTRINE [USP MONOGRAPH] | LUMEFANTRINE [USP-RS] | Q904464

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

2-Dibutylamino-1-[2, 7-dichloro-9-(4-chloro-benzylidene)-9H-fluoren-4-yl]-ethanol | 9H-Fluorene-4-methanol, 2, 7-dichloro-9-((4-chlorophenyl)methylene)-alpha-((dibutylamino)methyl)-, (9Z)-(-)- | LUMEFANTRINE [USP MONOGRAPH] | LUMEFANTRINE [USP-RS] | Q904464

Specifications & Purity

Moligand™, ≥98%(HPLC)

Biochemical and Physiological Mechanisms

Lumefantrine is is an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.

Storage

Room temperature

Shipped In

Normal

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Ferriprotoporphyrin IX inhibitor

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 488195785
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488195785
• Canonical Smiles: CCCCN(CCCC)CC(C1=CC(=CC2=C1C3=C(C2=CC4=CC=C(C=C4)Cl)C=C(C=C3)Cl)Cl)O
• IUPAC Name: 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol
• InChIKey: DYLGFOYVTXJFJP-MYYYXRDXSA-N
• INCHI: 1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-
• Isomeric SMILES: CCCCN(CCCC)CC(C1=CC(=CC\2=C1C3=C(/C2=C/C4=CC=C(C=C4)Cl)C=C(C=C3)Cl)Cl)O
• WGK Germany: 3
• Molecular Weight: 528.94
• Reaxy-Rn: 22352337
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22352337&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Fluorenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Fluorenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Fluorenes
• Alternative Parents: Chlorobenzenes Aralkylamines Aryl chlorides Trialkylamines Secondary alcohols 1,2-aminoalcohols Organopnictogen compounds Organochlorides Hydrocarbon derivatives Aromatic alcohols
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Fluorene - Chlorobenzene - Aralkylamine - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - 1,2-aminoalcohol - Tertiary aliphatic amine - Secondary alcohol - Tertiary amine - Organochloride - Organohalogen compound - Alcohol - Aromatic alcohol - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Amine - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene.
• External Descriptors: tertiary amine - secondary alcohol - monochlorobenzenes - fluorenes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (3 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

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Huh-7 (12904 Activities)

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GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

Discover Target: PMP22

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium berghei (192651 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium vivax (152 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Chikungunya virus (1339 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Melt Point(°C): 136 °C
• Molecular Weight: 528.900 g/mol
• XLogP3: 8.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 10
• Exact Mass: 527.155 Da
• Monoisotopic Mass: 527.155 Da
• Topological Polar Surface Area: 23.500 Ų
• Heavy Atom Count: 35
• Formal Charge: 0
• Complexity: 671.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

References

1. Yang Jinlan, Gao Yulan, Yang Li.  (2021)  Capillary-based fluorescence microsensor with polyoxometalates as nanozyme for rapid and ultrasensitive detection of artemisinin.  MICROCHIMICA ACTA,  189  (1): (1-8).  [PMID:34964917] [10.1007/s00604-021-05126-z]

2. Jiao Sha, Xiaoqing Yang, Xiaoran Hu, Zibo Huang, Zidan Cao, Yameng Wan, Renren Sun, Gaoliang Jiang, Haixia He, Yu Li, Tao Li, Baozeng Ren.  (2020)  Solubility determination, model evaluation, Hansen solubility parameter and thermodynamic properties of benflumetol in pure alcohol and ester solvents.  JOURNAL OF CHEMICAL THERMODYNAMICS,      [PMID:] [10.1016/j.jct.2020.106323]

3. Weisi Wang, Jun Li, Wenjing Qi, Ying Chen, Mengxiao Tian, Chuanchuan Wu, Yao Zhang, Yingfang Yu, Shuai Han, Xiumin Han, Liping Duan, Wenbao Zhang.  (2024)  Drug repurposing for hard-to-treat human alveolar echinococcosis: pyronaridine and beyond.  PARASITOLOGY,      [PMID:39508157] [10.1017/S0031182024001124]

4. Ji Yang, Peng Guo, Hongtao Luo, Xin Tang, Wei Liu, Xiaolin Ren.  (2025)  Lumefantrine ameliorates DSS-induced colitis by targeting FLI-1 to suppress NF-κB signaling.  Frontiers in Pharmacology,      [PMID:40717962] [10.3389/fphar.2025.1614978]

5. Chuyi Yu, Xiaobo Li, Keneng Cai, Weichi Jiang, Wanying Chen, Run Xia, Mengyao Xu, Jianjia Feng, Chengli Ling, Sheng Zhou, Yinhuan Chen, Feng Zeng, Qin Xu, Xiao He, Mingqiang Li, Jianping Song, Jianming Liang.  (2026)  Allicin-based biomimetic nanoparticles of the erythrocyte membrane for delivery of lumefantrine to enhance its antimalarial effect.  International Journal of Pharmaceutics-X,      [PMID:] [10.1016/j.ijpx.2026.100487]