≥96% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
Lupanine (D-Lupanine) is a natural ketonic derivative of Sparteine ( (+)-Sparteine ) with a ganglioplegic activity. Lupanine shows binding affinity for nicotinic receptor ( nAChR ) with a K i value of 500 nM
In Vitro
Lupanine shows binding affinity for nicotinic receptor with a K i value of 500 nM. While, Lupanine shows a very weak affinity for the muscarinic receptor with a K i value of 11000 nM. Lupanine (0-100 μM) is a weak agonist and desensitizer in SH-SY5Y cells, with EC 50 and DC 50 of 10.7 μM and 28.2 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Lupanine (100-300 mg/kg for i.p.; 175-700 mg/kg for p.o.) is much less toxic in one single injection in EOPS male Swiss mice (20-22 g) and Hartley guinea-pigs (400-500 g) . Lupanine (1-7.5 mg/kg; i.v.) is more efficient than Sparteine for antagonizing secondary reflex hypertension in carotid occlusion and hypotension resulting from the stimulation of the pneumogastric nerve in both the cat and the dog . Lupanine has an inhibitory action on nicotinic type hypertension produced by injection of Acetylcholine (500 p.g/kg i.v.) in the Atropine-treated dog . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Lupanine (D-Lupanine) is a natural ketonic derivative of Sparteine ( (+)-Sparteine ( HY-W008350 ) ) with a ganglioplegic activity. Lupanine shows binding affinity for nicotinic receptor ( nAChR ) with a K i value of 500 nM.
Condizioni di conservazione di stoccaggio
Protected from light,Store at -80°C
Spedito in
Dry ice packs + Cold packs
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
This compound belongs to the class of organic compounds known as sparteine, lupanine, and related alkaloids. These are alkaloids with a structure based on either sparteine, lupanine, or derivatives thereof. These are tetracyclic compounds made of two fused quinolizidine ring systems.
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Proprietà chimiche e fisiche
Peso molecolare
248.360 g/mol
XLogP3
1.600
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
0
Exact Mass
248.189 Da
Monoisotopic Mass
248.189 Da
Topological Polar Surface Area
23.600 Ų
Heavy Atom Count
18
Formal Charge
0
Complexity
356.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
4
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
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Recensioni
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Domande frequenti
What is the purity of this product?
This product is supplied at ≥96% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.
How is this product shipped?
This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 550-90-3, the molecular formula is C15H25ClN2O5, and the molecular weight is 348.82 g/mol. InChIKey JYIJIIVLEOETIQ-XDQVBPFNSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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