Velzatinib(M4205) - Moligand™,≥99% , CAS No.2590556-80-0

CAS: 2590556-80-0 Cat. No.: M650715 Formula: C₂₉H₃₂N₈O Peso molecolare: 508.62 PubChem CID: 155587867

QUALITÀ & PUREZZA Moligand™, ≥99%

Synonyms

[4-(Methyl-1H-pyrazol-4-yl)-benzyl] -(6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a] pyridin-3-yl]-pyrimidin-4-yl]-amine | MS-29449 | compound 32 [PMID: 36728508] | K3R | M4205 | M-4205 | Y6UHU32G5Z | GTPL11510 | 4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyra

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

M4205 is a c-KIT inhibitor, with an IC 50 of 10 nM for c-KIT V654A. M4205 has high activity on c-KIT mutations in exon 11, 13, 17.

Form:Solid

IC50& Target:c-KIT

Specifiche

Sinonimi

[4-(Methyl-1H-pyrazol-4-yl)-benzyl] -(6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a] pyridin-3-yl]-pyrimidin-4-yl]-amine | MS-29449 | compound 32 [PMID: 36728508] | K3R | M4205 | M-4205 | Y6UHU32G5Z | GTPL11510 | 4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyra

Specifiche e purezza

Moligand™,≥99%

Meccanismi biochimici e fisiologici

Velzatinib (M4205) is a multi-target inhibitor for PDGFRB, PDGFRA, CSF1R, c-Kit, FLT3, and LCK, with an IC50s of 2.6, 50, 5.5, 44, 141 and 141 nM, respectively. Velzatinib exhibits antitumor efficacy in xenograft mouse models.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Purezza

≥99%

Nomi e identificatori

Sorrisi canonici

CN1C=C(C=N1)C2=CC=C(C=C2)CNC3=NC=NC(=C3)C4=CN=C5N4C=CC(=C5)OCCCN6CCCC6

IUPAC Name

N-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine

InChIKey

LVMAULGVWBINFP-UHFFFAOYSA-N

INCHI

1S/C29H32N8O/c1-35-20-24(18-34-35)23-7-5-22(6-8-23)17-30-28-16-26(32-21-33-28)27-19-31-29-15-25(9-13-37(27)29)38-14-4-12-36-10-2-3-11-36/h5-9,13,15-16,18-21H,2-4,10-12,14,17H2,1H3,(H,30,32,33)

Isomeri SMILES

CN1C=C(C=N1)C2=CC=C(C=C2)CNC3=NC=NC(=C3)C4=CN=C5N4C=CC(=C5)OCCCN6CCCC6

CAS alternativo

2590556-80-0

PubChem CID

155587867

Peso molecolare

508.62

Proprietà chimiche e fisiche

• Solubilità: DMSO : 11.11 mg/mL (21.84 mM; ultrasonic and warming and heat to 66°C)
• Peso molecolare: 508.600 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 508.27 Da
• Monoisotopic Mass: 508.27 Da
• Topological Polar Surface Area: 85.400 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 715.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Domande frequenti

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2590556-80-0, the molecular formula is C29H32N8O, and the molecular weight is 508.62 g/mol. InChIKey LVMAULGVWBINFP-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.