M8 B hydrochloride - ≥99%(HPLC) , CAS No.883976-12-3

CAS: 883976-12-3 Cat. No.: M288345 Molecular Weight: 433

GRADE & PURITY ≥99%(HPLC)

Synonyms

N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride | N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide, monohydrochloride | M8-B Hydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

application：

M8-B hydrochloride has been used as a transient receptor potential melastatin-8 (TRPM8) channel antagonist to study its therapeutic efficiency on a mouse model of severe dry eye disease (DED) induced by the excision of extra-orbital lacrimal and Harderian glands.

Specifications

Synonyms

N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride | N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide, monohydrochloride | M8-B Hydrochloride

Specifications & Purity

≥99%(HPLC)

Biochemical and Physiological Mechanisms

Potent and selective TRPM8 channel blocker. Blocks cold- andicilin-induced TRPM8 activationin vitro(IC50values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC50> 20μM). Reduces body temperaturein vivo.M8-B is a selective an

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Purity

≥99%(HPLC)

Names and Identifiers

• Pubchem Sid: 488202140
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488202140
• Canonical Smiles: COC1=C(C=CC(=C1)CN(CCN)C(=O)C2=CC=CS2)OCC3=CC=CC=C3.Cl
• IUPAC Name: N-(2-aminoethyl)-N-[(3-methoxy-4-phenylmethoxyphenyl)methyl]thiophene-2-carboxamide;hydrochloride
• InChIKey: FMQJBHACRTZLME-UHFFFAOYSA-N
• INCHI: 1S/C22H24N2O3S.ClH/c1-26-20-14-18(9-10-19(20)27-16-17-6-3-2-4-7-17)15-24(12-11-23)22(25)21-8-5-13-28-21;/h2-10,13-14H,11-12,15-16,23H2,1H3;1H
• Isomeric SMILES: COC1=C(C=CC(=C1)CN(CCN)C(=O)C2=CC=CS2)OCC3=CC=CC=C3.Cl
• Molecular Weight: 433
• Reaxy-Rn: 12588502
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=12588502&ln=

Chemical and Physical Properties

• Solubility: Solvent:water, Max Conc. mg/mL: 4.33, Max Conc. mM: 10 with sonication; Solvent:DMSO, Max Conc. mg/mL: 43.3, Max Conc. mM: 100
• Sensitivity: Moisture sensitive
• Molecular Weight: 433.000 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 432.127 Da
• Monoisotopic Mass: 432.127 Da
• Topological Polar Surface Area: 93.000 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 473.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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