Margatossina, Channel blocker of K v1.1;Channel blocker of K v1.2;Channel blocker of K v1.3;Channel blocker of K v1.7, CAS No.145808-47-5, Channel blocker of K v1.1;Channel blocker of K v1.2;Channel blocker of K v1.3;Channel blocker of K v1.7

CAS: 145808-47-5 Cat. No.: M287709 Formula: C₁₇₈H₂₈₆N₅₂O₅₀S₇ Peso molecolare: 4178.96 Numero EC: 686-414-8 PubChem CID: 121596045
Disponibile su ordine
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
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Size
Germania (EU)
USA*
Price
Qty
100μg
M287709-100μg
Su ordinazione · 8–12 settimane
260,23€
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Why this grade

Moligand™ Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Conservare a -20°C Ships Cassetta del ghiaccio + cuscini per il ghiaccio Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Product Name
Margatossina, Channel blocker of K v1.1;Channel blocker of K v1.2;Channel blocker of K v1.3;Channel blocker of K v1.7, CAS No.145808-47-5
Sinonimi
UNII-6197NL836C | 6197NL836C | HB1083 | Margatossina | C178H286N52O50S7
Grado
Moligand™
Specifiche e purezza
Moligand™
Meccanismi biochimici e fisiologici
Potente bloccante dei canali KV1.3 (IC50= 36 pM). Non ha effetto sui canali attivati dal calcio. Riduce gli afflussi di calcio transmembrana indotti dal VEGF e la produzione di ossido nitrico nelle cellule endoteliali umane.
Sequenza
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH(Modifications: Disulfide bridge between 7 - 29, 13 - 34, 17 - 36)
Tipo di azione
CHANNEL BLOCKER
Meccanismo d'azione
Channel blocker of K v1.1;Channel blocker of K v1.2;Channel blocker of K v1.3;Channel blocker of K v1.7
CAS
145808-47-5
Tipo di molecola
Piccola molecola
Stoccaggio e spedizione
Condizioni di conservazione di stoccaggio
Conservare a -20°C
Spedito in
Cassetta del ghiaccio + cuscini per il ghiaccio

Documentazione

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Struttura 3D
Modello di struttura chimica interattiva





Obiettivi associati (umani)
KCNA7 Tclin Potassium voltage-gated channel subfamily A member 7 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNA3 Tclin Potassium voltage-gated channel subfamily A member 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNA2 Tclin Potassium voltage-gated channel subfamily A member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNA1 Tclin Potassium voltage-gated channel subfamily A member 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Informazioni genetiche
Alternate NamesUNII-6197NL836C | 6197NL836C | HB1083 | Margatossina | C178H286N52O50S7
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more
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What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 145808-47-5. InChIKey OVJBOPBBHWOWJI-FYNXUGHNSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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